Human Papillomavirus: The Equal Opportunity Pathogen.
Human Papillomavirus: The Equal Opportunity Pathogen.
复制标题
人乳头瘤病毒：机会均等的病原体。
DOI：
10.1093/infdis/jix058
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Gravitt,PattiE
中科院分区：
文献类型：
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作者：
Gravitt,PattiE
2003 年，在通过预防性疫苗预防人乳头瘤病毒 (HPV) 的初步报告显示，美国疾病控制与预防中心将女性生殖器 HPV 感染监测纳入到每两年一次的国家健康和营养检查调查 (NHANES) 中[1]。经过超过 10 年的随访，这些努力揭示了女性生殖器 HPV 的高负担和年龄特定分布，以及最近 HPV 疫苗接种对减少美国女性四价 HPV 疫苗 (4vHPV) 相关基因型的人群影响 [1-3]。在本期《传染病杂志》中，Gargano 等人报告了另一半人口（具有全国代表性的美国男性样本）中生殖器 HPV 的患病率，该样本于 2013 年至 2014 年首次纳入 NHANES [4]。这些数据与之前发表的女性估计值相比 [2]，证实美国男性和女性均承担生殖器 HPV 的负担。具体而言，42.2% 的人检测到具有 37 种 HPV 基因型（即高危 HPV [HR-HPV] 和/或低危 HPV）中任何一种或多种的阴茎 HPV 感染。
In 2003, following initial reports of high efficacy for prevention of human papillomavirus (HPV) through prophylactic vaccine, the Centers for Disease Control and Prevention incorporated surveillance for genital HPV infection in women as part of the biannual National Health and Nutrition Examination Surveys (NHANES)[1]. With> 10 years of follow-up, these efforts have illuminated the high burden and the age-specific distribution of female genital HPV and, most recently, the population impact of HPV vaccination in reducing quadrivalent HPV vaccine (4vHPV)–associated genotypes among US women [1–3]. In this issue of The Journal of Infectious Diseases, Gargano et al report the genital HPV prevalence in the other half of the population—a nationally representative sample of US men, included in the NHANES for the first time in 2013–2014 [4]. These data, compared with previously published estimates in women [2], confirm that the burden of genital HPV is shared equally by men and women in the United States. Specifically, penile HPV infection with any one or more of 37 HPV genotypes (ie, high-risk HPV [HR-HPV] and/or low-risk HPV) was detected in 42.2% of