Control of polymeric nanoparticle size to improve therapeutic delivery.
Control of polymeric nanoparticle size to improve therapeutic delivery.
复制标题
DOI：
10.1016/j.jconrel.2015.10.006
复制
发表时间：
2015-12-10
期刊：
影响因子：
--
通讯作者：
Mao HQ
中科院分区：
文献类型：
--
作者：
Hickey JW;Santos JL;Williford JM;Mao HQ
随着纳米颗粒 (NP) 介导的药物递送研究的不断扩展，了解控制 NP 与生物环境相互作用的参数变得至关重要。从这些参数的研究中确定的原理可用于设计新的纳米粒子，赋予独特的功能，确定新的用途，并改进纳米粒子配方的临床转化。一个关键的设计参数是 NP 尺寸。人们已经开发出新的方法来生产纳米粒子，增强了对纳米粒子尺寸在 10 至 200 nm 之间的控制，该尺寸范围与通过血管内和特定位点输送的物理和生化靶向最相关。本综述重点介绍了最适合生成具有窄尺寸分布的聚合物纳米颗粒的三种著名技术：自组装、基于微流体的制备和闪速纳米沉淀。此外，本文还分析了纳米粒子大小对分子尺度（蛋白质-纳米粒子相互作用）以及组织和系统尺度（纳米粒子的对流和扩散运输）的生物命运和运输特性的影响。这些分析强调了 NP 大小控制在考虑 NP 递送载体的临床转化和治疗结果评估中的重要性。
As nanoparticle (NP)-mediated drug delivery research continues to expand, understanding parameters that govern NP interactions with the biological environment becomes paramount. The principles identified from the study of these parameters can be used to engineer new NPs, impart unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations. One key design parameter is NP size. New methods have been developed to produce NPs with increased control of NP size between 10 to 200 nm, a size range most relevant to physical and biochemical targeting through both intravascular and site-specific deliveries. Three notable techniques best suited for generating polymeric NPs with narrow size distributions are highlighted in this review: self-assembly, microfluidics-based preparation, and flash nanoprecipitation. Furthermore, the effect of NP size on the biological fate and transport properties at the molecular scale (protein-NP interactions) and the tissue and systemic scale (convective and diffusive transport of NPs) are analyzed here. These analyses underscore the importance of NP size control in considering clinical translation and assessment of therapeutic outcomes of NP delivery vehicles.