Mesoscopic kinetics and its applications in protein synthesis
Mesoscopic kinetics and its applications in protein synthesis
复制标题
DOI：
10.1007/4735_86
复制
发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Ehrenberg, Mans
中科院分区：
文献类型：
--
作者：
Elf, Johan;Paulsson, Johan;Ehrenberg, Mans
分子生物学是通过遗传学和核酸化学的统一而出现的，这是随着双螺旋的发现而发生的（沃森和克里克1953）。因此，分子生物学可以被定义为通过操纵DNA进行遗传实验的所有技术的总和。这些技术发展的一个结果是对越来越多的生物体的基因组进行大规模测序。然而，从这一发展中可以清楚地看出，遗传信息本身不足以掌握细胞和多细胞生物体最有趣的功能和进化方面。事实上，理解基因型如何导致表型取决于迄今为止在很大程度上与分子生物学研究无关的领域的概念和技术，如物理学，数学和工程学。从这些和其他科学领域的零碎信息中，必须产生新的工具，以便能够理解动态的、适应的和发展的生命系统，这些生命系统以某种方式从基因组给出的指令中形成。这些工具的数量不断增加，并将其整合到实验和理论方法中，以以前无法理解的方式来理解复杂的生物过程，这可能是定义系统生物学的一种方式，类似于上述分子生物学的定义。
AbstractMolecular biology emerged through unification of genetics and nucleic acid chemistry that took place with the discovery of the double helix (Watson and Crick 1953). Accordingly, molecular biology could be defined as the sum of all techniques used to perform genetic experiments by manipulating DNA. One consequence of the development of these techniques is large-scale sequencing of genomes from an ever increasing number of organisms. However, it became clear from this development that genetic information per se is not enough to grasp the most interesting functional and evolutionary aspects of cells and multi-cellular organisms. In fact, understanding how genotype leads to phenotype depends on concepts and techniques from areas that so far have been largely alien to molecular biological research, like physics, mathematics, and engineering. From the bits and pieces from these and other scientific fields new tools must be generated to make possible an understanding of the dynamic, adapting, and developing living systems that somehow take shape from the instructions given by their genomes. The growing total of these tools and their integration in experimental and theoretical approaches to understand complex biological processes in ways previously out of reach could be a way to define systems biology, in analogy with the above definition of molecular biology.