EFFECT OF INSULIN CONCENTRATION, SUBCUTANEOUS FAT THICKNESS AND SKIN TEMPERATURE ON SUBCUTANEOUS INSULIN ABSORPTION IN HEALTHY-SUBJECTS
EFFECT OF INSULIN CONCENTRATION, SUBCUTANEOUS FAT THICKNESS AND SKIN TEMPERATURE ON SUBCUTANEOUS INSULIN ABSORPTION IN HEALTHY-SUBJECTS
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DOI：
10.1007/bf00408474
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发表时间：
1994-04-01
期刊：
影响因子：
8.2
通讯作者：
CHANTELAU, E
中科院分区：
文献类型：
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作者：
SINDELKA, G;HEINEMANN, L;CHANTELAU, E
在脐周注射可溶性人U40-或U100-胰岛素（0.15 IU/kg）后45分钟内，评估了50例健康研究受试者（21例女性，29例男性;年龄26 ± 3岁，BMI 22.5 ± 1.8 kg/m2;平均值± SD）的皮下胰岛素吸收动力学。通过超声测量皮下脂肪厚度，并记录注射部位的皮肤温度。在30分钟内，使用U40-胰岛素后，血清胰岛素浓度从基础值37 +/- 15增加到140 +/- 46 pmol/l，使用U100-胰岛素后，从36 +/- 10增加到116 +/- 37 pmol/l（p < 0.001）。45分钟后，U40-胰岛素组血清胰岛素浓度为164 +/- 43 pmol/l，U100-胰岛素组为128 +/- 35 pmol/l（p < 0.001）。血糖水平下降和C肽抑制相当。注射U40-和U100-胰岛素后30和45 min血清胰岛素水平与皮温呈正相关（p < 0.0008），与皮下脂肪厚度呈负相关（p < 0.009）。总之，U40-胰岛素的胰岛素浓度较低、皮肤温度较高和注射部位皮下脂肪组织较薄与皮下胰岛素吸收加速和增强相关。
Subcutaneous insulin absorption kinetics were assessed in 50 healthy study subjects (21 female, 29 male; age 26 +/- 3 years, BMI 22.5 +/- 1.8 kg/m2; mean +/- SD) during 45 min after periumbilical injection of soluble human U40- or U100-insulin (0.15 IU/kg). Subcutaneous fat thickness was measured by ultrasound, and skin temperature at the injection site was registered. Serum insulin concentrations increased within 30 min from basal values of 37 +/- 15 to 140 +/- 46 pmol/l after U40-insulin and from 36 +/- 10 to 116 +/- 37 pmol/l after U100-insulin (p < 0.001). After 45 min serum insulin concentrations were 164 +/- 43 pmol/l with U40-insulin and 128 +/- 35 pmol/l with U100-insulin (p < 0.001). Decline in blood glucose levels and suppression of C-peptide were comparable. The serum insulin levels reached 30 and 45 min after U40- and U100-insulin injection were positively correlated with skin temperature (p < 0.0008), and negatively correlated with subcutaneous fat thickness (p < 0.009). In conclusion, the lower insulin concentration of U40-insulin, higher skin temperature, and a thinner subcutaneous fat tissue at the injection site are associated with accelerated and enhanced subcutaneous insulin absorption.