Absolute configuration of 2-(tributylstannyl)pyrrolidine by anomalous dispersion X-ray analysis
Absolute configuration of 2-(tributylstannyl)pyrrolidine by anomalous dispersion X-ray analysis
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DOI：
10.1021/jo048569w
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发表时间：
2005-01-07
影响因子：
3.6
通讯作者：
Vicic, DA
中科院分区：
文献类型：
--
作者：
Gawley, RE;Narayan, S;Vicic, DA
对映纯的2-（三丁基锡烷基）吡咯烷氢碘酸盐可以通过相应的N-Boc化合物的TMSI处理以优异的产率制备，N-Boc化合物又通过不对称去质子化（s-BuLi（.）金雀花碱）和甲锡烷基化。获得了适合于X射线分析的氢碘酸盐晶体，尽管丁基存在一些无序，但使用反常色散的分析确定了绝对构型为S。
Enantiopure 2-(tributylstannyl)pyrrolidine hydroiodide may be prepared in excellent yield by TMSI treatment of the corresponding N-Boc compound, which is in turn prepared by asymmetric deprotonation (s-BuLi(.)sparteine) and stannylation, as described in the literature. Crystals of the hydroiodide salt suitable for X-ray analysis were obtained, and although there is some disorder about the butyl groups, analysis using anomalous dispersion establishes the absolute configuration as S.