Elevated hair cortisol levels in chronically stressed dementia caregivers
Elevated hair cortisol levels in chronically stressed dementia caregivers
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DOI：
10.1016/j.psyneuen.2014.04.021
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发表时间：
2014-09-01
影响因子：
3.7
通讯作者：
Kirschbaum, Clemens
中科院分区：
文献类型：
--
作者：
Stalder, Tobias;Tietze, Antje;Kirschbaum, Clemens
头发皮质醇浓度（HCC）被认为反映了长期皮质醇的综合水平，并被提议作为慢性心理压力的一个有前景的内分泌标志物。目前的研究检查了肝癌与护理负担的关系，护理负担是人类慢性压力的一种成熟的自然模型。对 20 名患有痴呆症的亲属的照顾者和 20 名年龄和性别相匹配的非照顾者对照者进行了 HCC 和相关心理社会数据的检查。结果显示，与非护理人员对照组相比，痴呆症护理人员的 HCC 发病率升高 (F-(1,F-38) = 4.4，p = .04，eta(2)(p) = .10）。此外，在护理人员中，观察到 HCC 与自我报告的护理负担呈正相关（r = .43，p = .058）以及与抑郁呈正相关（r = .48，p = .045）的趋势。未发现 HCC 与主观测量之间存在其他关联。这些发现与 HCC 敏感地捕捉压力暴露群体的内分泌异常的观点一致。 (C) 2014 Elsevier Ltd. 保留所有权利。
Hair cortisol concentrations (HCC) are assumed to reflect integrated long-term cortisol levels and have been proposed as a promising endocrine marker of chronic psychological stress. The current study examined HCC in relation to caregiving burden, a well-established naturalistic model of chronic stress in humans. HCC and relevant psychosocial data were examined in 20 caregivers of relatives with dementia and 20 non-caregiver controls matched for age and sex. Results revealed elevated HCC in dementia caregivers compared to non-caregiver controls (F-(1,F-38) = 4.4, p = .04, eta(2)(p) = .10). Further, within caregivers, a trend for a positive association of HCC with self-reported caregiving burden (r = .43, p = .058) and a positive association with depressiveness (r = .48, p = .045) were observed. No other associations between HCC and subjective measures were seen. These findings concur with the notion that HCC sensitively capture endocrine aberrations in stress-exposed groups. (C) 2014 Elsevier Ltd. All rights reserved.