Pre- and postmortem imaging of transplanted cells.
Pre- and postmortem imaging of transplanted cells.
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DOI：
10.2147/ijn.s83557
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发表时间：
2015
影响因子：
8
通讯作者：
Lukomska B
中科院分区：
文献类型：
--
作者：
Andrzejewska A;Nowakowski A;Janowski M;Bulte JW;Gilad AA;Walczak P;Lukomska B
基于干细胞和祖细胞移植的治疗干预引起了越来越多的兴趣。许多疾病的适应症，包括心血管、中枢神经和肌肉骨骼系统，成功的临床前研究激发了这种兴趣。这一领域的进一步进展取决于能否获得有助于明确识别和表征移植细胞的技术。这些方法对于优化细胞输送、提高细胞存活率和评估移植细胞的功能整合是非常有价值的。以下是对目前可用的细胞检测和跟踪方法的重点概述，这些方法涵盖了从死前到死后细胞识别的整个范围。
Therapeutic interventions based on the transplantation of stem and progenitor cells have garnered increasing interest. This interest is fueled by successful preclinical studies for indications in many diseases, including the cardiovascular, central nervous, and musculoskeletal system. Further progress in this field is contingent upon access to techniques that facilitate an unambiguous identification and characterization of grafted cells. Such methods are invaluable for optimization of cell delivery, improvement of cell survival, and assessment of the functional integration of grafted cells. Following is a focused overview of the currently available cell detection and tracking methodologies that covers the entire spectrum from pre- to postmortem cell identification.