EFFECTS OF CONTINUOUS ADMINISTRATION OF OXYTOCIN BY AN ACCUREL DEVICE ON PARTURITION IN THE RAT AND ON DEVELOPMENT AND DIURESIS IN THE OFFSPRING
EFFECTS OF CONTINUOUS ADMINISTRATION OF OXYTOCIN BY AN ACCUREL DEVICE ON PARTURITION IN THE RAT AND ON DEVELOPMENT AND DIURESIS IN THE OFFSPRING
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DOI：
10.1677/joe.0.1010121
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发表时间：
1984-01-01
影响因子：
4
通讯作者：
KRUISBRINK, J
中科院分区：
文献类型：
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作者：
BOER, GJ;KRUISBRINK, J
一种基于微孔Accurel聚丙烯管的可控输送模块，植入S.C.在大鼠体内和体外都被用来释放催产素至少40天。使用每天约650 ng催产素的剂量率，并在怀孕第17天将该装置植入大鼠体内，证实了催产素在促进分娩中的已知生理作用。母亲体内催产素浓度的增加引起了不良影响；第一只幼崽被驱逐时产程延长，出生体重减轻。出生后，幼崽的身体发育也受到影响，尽管当幼崽开始独立进食时，部分恢复。幼崽出生前和出生后暴露在接受催产素治疗的母亲的环境中，在1个月的时间里，它们的体内水分周转率都有所降低。年纪大了。对分娩过程和哺乳期的影响可能分别通过阻断子宫和乳腺催产素受体来解释，从而抑制对脉动性内源性催产素分泌的适当反应。水代谢的变化与异源激素血管加压素的描述相反，不太容易解释，因为母亲的催产素不应该通过胎盘。临床上使用催产素引产和哺乳可能会有迄今未被认识到的副作用。
A controled-delivery module based on microporous Accurel polypropylene tubing, implanted s.c. in the rat, was used to release oxytocin for at least 40 days both in vitro and in vivo. Using a dosage rate of approximately 650 ng oxytocin per day and implanting the device in rats on day 17 of pregnancy, the known physiological action of oxytocin in advancing labor was confirmed. The increased concentrations of oxytocin in the mothers gave rise to adverse effects; the course of labor was protracted during expulsions of the first pups and the birth weight was reduced. Postnatally, body development of the pups was also affected, although there was partial recovery when the pups started to feed independently. Both pre- and postnatal exposure of pups to an oxytocin-treated mother reduced their body water turnover measured at 1 mo. of age. The effects on the course of parturition and during lactation might be explained by a blockade of uterine and mammary gland oxytocin receptors, respectively, thereby inhibiting a proper response to pulsatile endogenous oxytocin secretion. The changes in water metabolism, which are opposite to those described for the heterologous hormone vasopressin, are less easy to explain since maternal oxytocin is not supposed to pass the placenta. Clinical use of oxytocin for induction of labor and lactation may have hitherto unrecognized side effects.