Regulation of cadherin adhesive activity.
Regulation of cadherin adhesive activity.
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DOI：
10.1083/jcb.148.3.399
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发表时间：
2000-02-07
影响因子：
7.8
通讯作者：
Gumbiner, B M
中科院分区：
文献类型：
--
作者：
Gumbiner, B M
细胞之间的粘附相互作用是动态的，并在组织发育和稳态过程中受到调节。钙粘蛋白是参与所有实体组织发育和维持的主要细胞间粘附分子（Takeichi，1991; Gumbiner，1996）。因此，钙粘蛋白介导的粘附和相关的粘附连接的调节被认为是细胞间粘附相互作用的动力学基础。一种主要的调节形式发生在钙粘蛋白基因表达水平。钙粘蛋白的表达水平影响粘附的强度（Steinberg和Takeichi，1994），并且所表达的钙粘蛋白的类型决定细胞相互作用的特异性（Nose等人，1988年）和相互作用的性质。然而，有越来越多的证据表明，钙粘蛋白粘附活性的转录后调节是负责许多动态的，快速变化的细胞相互作用的基础组织形态和稳态。钙粘蛋白粘附活性的调节机制是这篇小综述的主题。
Adhesive interactions between cells are dynamic and regulated during tissue development and homeostasis. Cadherins are major cell–cell adhesion molecules involved in the development and maintenance of all solid tissues (Takeichi, 1991; Gumbiner, 1996). Therefore, regulation of cadherin-mediated adhesion and the associated adherens junctions is thought to underlie the dynamics of the adhesive interactions between cells. A major form of regulation occurs at the level of cadherin gene expression. The level of cadherin expression influences the strength of adhesion (Steinberg and Takeichi, 1994), and the type of cadherin expressed determines the specificity of cell interactions (Nose et al., 1988) and properties of the interactions. However, there is accumulating evidence that posttranscriptional regulation of cadherin adhesive activity is responsible for many of the dynamic, rapid changes in cell interactions that underlie tissue morphogenesis and homeostasis. The mechanisms underlying the regulation of cadherin adhesive activity is the topic of this Mini-Review.