Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels.
Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels.
复制标题
通过三维微血管网络向肿瘤输送氧气的理论模拟。
DOI：
10.1007/978-1-4615-4863-8_74
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发表时间：
1998
影响因子：
--
通讯作者：
Dewhirst,MW
中科院分区：
文献类型：
--
作者：
Secomb,TW;Hsu,R;Braun,RD;Ross,JR;Gross,JF;Dewhirst,MW
缺氧癌细胞对照射和某些类型的化疗有抵抗力。当这些方法用于治疗肿瘤时，小的缺氧区域的存在会影响结果。因此，在显微水平上了解决定肿瘤中氧分压（pO2）的因素是很重要的。这些因素包括肿瘤的供氧量，这取决于血液的流速和含氧量以及组织内微血管的排列，以及组织的耗氧量（Vaupel, 1979）。
Hypoxic cancer cells are resistant to irradiation and to some types of chemotherapy. When these methods are used to treat tumors, presence of small hypoxic regions can compromise the outcome. Therefore, it is important to understand the factors determining the partial pressure of oxygen (pO2) in tumors at the microscopic level. These factors include the oxygen supply to the tumor, which depends on the flow rate and oxygen content of blood and the arrangement of microvessels within the tissue, and the rate of oxygen consumption by the tissue (Vaupel, 1979).