Horizontal saccade dynamics across the human life span
Horizontal saccade dynamics across the human life span
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DOI：
10.1167/iovs.05-1311
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发表时间：
2006-06-01
影响因子：
4.4
通讯作者：
Hutchings, Natalie
中科院分区：
文献类型：
--
作者：
Irving, Elizabeth L.;Steinbach, Martin J.;Hutchings, Natalie
目的.研究眼跳动态作为年龄的函数，以确定它们是否遵循Weale衰老模型预测的发展和衰退模式。195名年龄在3岁到86岁之间的受试者在视觉引导下对点刺激做出了大小从1度到60度的水平prosaccade。用基于视频的眼动仪双眼记录眼动，以120 Hz采样。扫视的潜伏期，准确性和速度进行了测量和分析作为年龄的函数。平均扫视潜伏期从3岁时的439 Ins下降到14岁时的172 Ins，随后是一段相对稳定的时期，直到50岁，最后逐渐增加到80岁时的264 Ins。对于扫视准确性（幅度增益），囊大小与年龄之间存在统计学显著（P < 0.05）的交互作用。随着年龄的增长和眼跳大小的增加，参与者的高测量眼跳越来越多。平均年龄组扫视渐近峰值速度（V-max）在儿童期从3岁时的446度/秒增加到14岁时的610度/秒的峰值，然后随着年龄的增长逐渐下降到>= 80岁的参与者的约345度/秒。年龄影响扫视的潜伏期、准确性和速度。对于每一个参数，都有不同的发育和衰退模式，这可能与控制每一种功能的大脑部分的发育和衰老方式有关。
PURPOSE. To investigate saccade dynamics as a function of age to determine whether they follow the pattern of development and decline predicted by Weale's model of aging.METHODS. One hundred ninety-five participants between the ages of 3 and 86 years made visually guided horizontal prosac-cades ranging in size from 1 degrees to 60 degrees in response to dot stimuli. Eye movements were recorded binocularly with a video-based eye tracker, sampling at 120 Hz. Saccadic latency, accuracy, and velocity were measured and analyzed as a function of age.RESULTS. Mean saccadic latency decreased from 439 Ins at 3 years to 172 Ins at 14 years, followed by a period of relative stability to age 50 and finally, gradually increased to 264 Ins at :80 years. For saccadic accuracy (amplitude gain), there was a statistically significant (P < 0.05) interaction between sac-cade size and age. Participants made increasingly hypometric saccades as age and saccade size increased. Average age group saccadic asymptotic peak velocity (V-max) increased during childhood from 446 deg/s at age 3, to a peak of 610 deg/s at 14 years and then gradually declined with age to approximately 345 deg/s for participants >= 80 years.CONCLUSIONS. Age affected saccadic latency, accuracy, and velocity. For each parameter there was a different pattern of development and decline probably related to the way in which the portion of the brain that controls each function develops and ages.