A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor
A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor
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DOI：
10.1093/chemse/bjh104
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发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
DeSimone, JA
中科院分区：
文献类型：
--
作者：
Lyall, V;Heck, GL;DeSimone, JA
Materials and methodsAll protocols were approved by the IACUC of Virginia Commonwealth University. The AI-salt taste receptor was investigated by RT–PCR, measurement of apical Na+ fluxes in polarized fungiform TRCs, and chorda tympani (CT) nerve recordings. The CT responses to salts were recorded in Sprague–Dawley rats, wildtype (WT) mice (C57BL/6J) and homozygous VR-1 knockout (KO; B6. 129S4-Trpv1™ 1jul) mice in the presence of benzamil (Bz; a more potent and specific blocker of epithelial Na+ channels than amiloride), the vanilloids RTX and CAP, the VR-1 antagonist SB-366791, and at elevated temperatures (Lyall et al., 2004).
