Circulating MicroRNAs as Minimally Invasive Biomarkers for Cancer Theragnosis and Prognosis.
Circulating MicroRNAs as Minimally Invasive Biomarkers for Cancer Theragnosis and Prognosis.
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循环microRNA作为癌症治疗和预后的微创生物标志物。
DOI：
10.3389/fgene.2011.00007
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发表时间：
2011
影响因子：
3.7
通讯作者：
Cho WC
中科院分区：
文献类型：
--
作者：
Cho WC
癌症治疗和预后迫切需要发现新的癌症生物标志物，在许多可能的样本类型中，血液被认为是这一发现的理想选择，因为它可以以微创的方式容易地收集。过去几年的结果已经确定微小RNA（miRNA）的定量是检测和预测癌症的一种有前途的方法。事实上，越来越多的研究表明，循环癌症相关的miRNA很容易在血浆或血清中测量，它们可以有力地区分癌症患者和健康对照，以及区分预后良好和预后不良的患者。此外，最近的研究结果也表明循环miRNA在癌症筛查，监测和治疗中的潜力。本文综述了近年来循环miRNAs与肿瘤关系的最新研究成果，重点阐述了循环miRNAs作为肿瘤诊断和预后的微创生物标志物的潜力。
Novel cancer biomarker discovery is urgently needed for cancer theragnosis and prognosis, and among the many possible types of samples, blood is regarded to be ideal for this discovery as it can be collected easily in a minimally invasive manner. Results of the past few years have ascertained the quantification of microRNA (miRNA) as a promising approach for the detection and prognostication of cancer. Indeed, an increasing number of studies have shown that circulating cancer-associated miRNAs are readily measured in plasma or serum and they can robustly discriminate cancer patients from healthy controls, as well as distinguishing between good-prognosis and poor-prognosis patients. Furthermore, recent findings also suggest the potential of circulating miRNAs in the screening, monitoring, and treatment of cancer. This article summarizes the most significant and latest discoveries of original researches on circulating miRNAs involvement in cancer, focusing on the potential of circulating miRNAs as minimally invasive biomarkers for cancer theragnosis and prognosis.