Prenatal polychlorinated biphenyl exposure is associated with decreased gestational length but not birth weight: archived samples from the Child Health and Development Studies pregnancy cohort.
Prenatal polychlorinated biphenyl exposure is associated with decreased gestational length but not birth weight: archived samples from the Child Health and Development Studies pregnancy cohort.
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DOI：
10.1186/1476-069x-11-49
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发表时间：
2012-07-20
期刊：
影响因子：
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通讯作者：
Factor-Litvak P
中科院分区：
文献类型：
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作者：
Kezios KL;Liu X;Cirillio PM;Kalantzi OI;Wang Y;Petreas MX;Park JS;Bradwin G;Cohn BA;Factor-Litvak P
已知的内分泌干扰物多氯联苯（PCBs）于1979年被禁止，但仍然存在于环境中。以前的研究是不一致的产前暴露于多氯联苯和怀孕的结果。我们调查了产前暴露于多氯联苯与妊娠期长短和出生体重之间的关系。从儿童健康和发展研究参与者中随机选择了600名婴儿（出生于1960年至1963年），随后在青春期，我们测量了产妇产后血清（分娩后三天内）中的11种PCB同系物。根据报告的末次月经第一天（LMP）和分娩日期计算妊娠时间。线性回归用于估计PCB暴露与胎龄和出生体重之间的关联，调整潜在的混杂因素。根据假设的生物作用（1b（弱苯巴比妥诱导剂的总和）、2b（有限二恶英活性的总和）和3（CYP 1A和CYP 2b诱导剂的总和））或邻位取代程度（单、二、三）对多氯联苯进行分组。二次分析研究了多氯联苯总接触量与个别同系物接触量之间的关系。单邻位取代的多氯联苯每增加一个单位，就会减少0.30周（95%置信区间（CI）-0.59，-0.016），相当于妊娠期缩短2.1天（95% CI-4.13，-0.11）。估计二邻位取代的多氯联苯（减少1.4天;（95% CI −2.9，0.1））和第3组多氯联苯（减少0.84天;（95% CI −1.8，0.11））也存在类似的关联。我们发现类似的协会在特定的同源物分析和同源物的总和。我们的研究提供了新的证据，表明PCB暴露缩短了人类的妊娠期。这可能对人群暴露产生公共卫生影响。
Polychlorinated biphenyls (PCBs), known endocrine disruptors, were banned in 1979 but persist in the environment. Previous studies are inconsistent regarding prenatal exposure to PCBs and pregnancy outcomes. We investigated associations between prenatal exposure to PCBs and gestational length and birth weight. In a sample of 600 infants (born between 1960 and 1963) randomly selected from Child Health and Development Studies participants followed through adolescence we measured 11 PCB congeners in maternal post partum sera (within three days of delivery). Length of gestation was computed from the reported first day of the last menstrual period (LMP) and delivery date. Linear regression was used to estimate associations between PCB exposure and gestational age and birth weight, adjusting for potential confounders. PCBs were grouped according to hypothesized biological action (1b (sum of weak phenobarbital inducers), 2b (sum of limited dioxin activity), and 3 (sum of CYP1A and CYP2b inducers)) or degree of ortho- substitution (mono, di, tri). Secondary analyses examined associations between total PCB exposure and exposure to individual congeners. Each unit increase in mono-ortho substituted PCBs was associated with a 0.30 week decrease (95% confidence interval (CI) -0.59, -0.016), corresponding to a 2.1 (95% CI −4.13, -0.11) day decrease in length of gestation. Similar associations were estimated for di-ortho substituted PCBs, (1.4 day decrease; (95% CI −2.9, 0.1)) and group 3 PCBs (0.84 day decrease; (95% CI −1.8, 0.11). We found similar associations in congener specific analyses and for the sum of congeners. Our study provides new evidence that PCB exposure shortens length of gestation in humans. This may have public health implications for population exposures.