Neovascular glaucoma after photoradiation therapy for uveal melanoma.
Neovascular glaucoma after photoradiation therapy for uveal melanoma.
复制标题
葡萄膜黑色素瘤光放射治疗后新生血管性青光眼。
DOI：
10.1001/archopht.1984.01040030659012
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发表时间：
1984
影响因子：
--
通讯作者：
T. Weingeist
中科院分区：
文献类型：
--
作者：
R. Lewis;D. Tse;C. Phelps;T. Weingeist
我们描述了两个病人（两只眼睛）与新生血管性青光眼后，光辐射治疗（PRT）睫状体和虹膜黑色素瘤。治疗8个月后，一只眼睛的组织学检查显示广泛的肿瘤坏死。第二例虹膜黑色素瘤患者在6个月后显示病变完全临床消失，虹膜新生血管消退。新生血管性青光眼的病因尚不明确。PRT诱导的显著肿瘤坏死可能导致血管增殖因子的释放，进而导致发红和新生血管性青光眼的发展。
We describe two patients (two eyes) with neovascular glaucoma following photoradiation therapy (PRT) for ciliary body and iris melanoma. Histopathologic examination in one eye eight months after treatment disclosed widespread tumor necrosis. The second patient with iris melanoma showed total clinical disappearance of the lesion and regression of iris neovascularization six months later. The cause of the neovascular glaucoma is uncertain. The marked tumor necrosis induced by PRT might have resulted in release of a vasoproliferative factor that, in turn, led to the development of rubeosis and neovascular glaucoma.