TrkB/BDNF signalling patterns the sympathetic nervous system
TrkB/BDNF signalling patterns the sympathetic nervous system
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DOI：
10.1038/ncomms9281
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发表时间：
2015-09-01
影响因子：
16.6
通讯作者：
Kulesa, Paul M.
中科院分区：
文献类型：
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作者：
Kasemeier-Kulesa, Jennifer C.;Morrison, Jason A.;Kulesa, Paul M.
交感神经系统对维持哺乳动物体内平衡至关重要。这个错综复杂的网络，由位于脊髓的神经节前神经元和构成椎体交感神经节链的神经节后神经元组成，是如何在发育过程中产生的还不完全清楚。这个问题尤其复杂，因为交感神经节的椎链来源于“初级”交感神经节的背侧迁移，而初级交感神经节最初位于其未来的突触前伙伴腹侧几百微米处。在这里，我们报告离散神经节的背侧迁移不是单个细胞的简单迁移，而是由神经节前和神经节后神经元的广泛相互作用介导的一个更加精心编排的过程。如果没有与神经节前轴突接触，则不会发生背侧迁移，这是由BDNF/TrkB信号介导的。因此，神经节前轴突释放的BDNF对trkb阳性交感神经元起化学作用，以形成周围神经系统的模式。
The sympathetic nervous system is essential for maintaining mammalian homeostasis. How this intricately connected network, composed of preganglionic neurons that reside in the spinal cord and post-ganglionic neurons that comprise a chain of vertebral sympathetic ganglia, arises developmentally is incompletely understood. This problem is especially complex given the vertebral chain of sympathetic ganglia derive secondarily from the dorsal migration of 'primary' sympathetic ganglia that are initially located several hundred microns ventrally from their future pre-synaptic partners. Here we report that the dorsal migration of discrete ganglia is not a simple migration of individual cells but a much more carefully choreographed process that is mediated by extensive interactions of pre- and post-ganglionic neurons. Dorsal migration does not occur in the absence of contact with preganglionic axons, and this is mediated by BDNF/TrkB signalling. Thus BDNF released by preganglionic axons acts chemotactically on TrkB-positive sympathetic neurons, to pattern the developing peripheral nervous system.