Malignant vascular tumours of the pleura in "asbestos" workers and endothelial differentiation in malignant mesothelioma
Malignant vascular tumours of the pleura in "asbestos" workers and endothelial differentiation in malignant mesothelioma
复制标题
DOI：
10.1136/thorax.55.10.860
复制
发表时间：
2000-10-01
期刊：
影响因子：
10
通讯作者：
Gibbs, AR
中科院分区：
文献类型：
--
作者：
Attanoos, RL;Suvarna, SK;Gibbs, AR
背景：本文报道3例胸膜弥漫性恶性血管肿瘤，其临床和病理表现与恶性间皮瘤相似（即所谓的“假性间皮瘤”）。所有人都有接触石棉的职业史。讨论了这些肿瘤与间皮瘤和石棉暴露的关系。方法：对92例胸膜间皮瘤及上述3种肿瘤进行血管标志物（CD31、CD34、血管性血友病因子）表达的免疫组化分析，探讨间皮瘤与这3种肿瘤的组织发生关系。对三例肺组织进行了电镜纤维分析，以评估石棉纤维含量。结果：弥漫性胸膜上皮样血管内皮瘤在临床和病理上可能与恶性间皮瘤非常相似，但在92例胸膜间皮瘤中，没有一例显示CD31、CD34和血管性血液病因子的表达。虽然这三个病例都声称接触过石棉，但只有在病例2中通过光学显微镜才能看到典型石棉的含铁体，并且只有在这个主题中，与未接触背景人群中看到的范围相比，石棉纤维含量才有所提高。胸膜上皮样血管内皮瘤的潜伏期为18 ~ 60年。结论间皮瘤不存在内皮分化，应与间皮瘤明确区分。从这个小的系列中，没有明确的胸膜上皮样血管内皮瘤和暴露于石棉之间的联系，但需要进一步的调查。
Background-Three cases of diffuse malignant vascular tumours of the pleura are described which mimicked malignant mesothelioma clinically and pathologically (so called "pseudomesothelioma"). All had occupational histories of exposure to asbestos. The relationship of these tumours to mesothelioma and asbestos exposure is discussed.Methods-To examine the histogenetic relationship between mesothelioma and these three tumours an immunohistochemical analysis of vascular marker (CD31, CD34, and Von Willebrand factor) expression was undertaken in 92 cases of pleural mesothelioma, in addition to these three tumours. Electron microscopic fibre analysis of lung tissue was performed on each of the three cases to assess asbestos fibre content.Results-Diffuse pleural epithelioid haemangioendotheliomas may closely resemble malignant mesothelioma clinically and pathologically but, of the 92 pleural mesotheliomas tested, none showed expression of CD31, CD34, and Von Willebrand factor. Although all three cases had claimed exposure to asbestos, ferruginous bodies typical of asbestos were only seen by light microscopy in case 2, and only in this subject was the asbestos fibre content raised in comparison with the range seen in a non-exposed background population. The latent period in the pleural epithelioid haemangioendotheliomas ranged from 18 to 60 years.Conclusions Endothelial differentiation does not appear to occur in mesothelioma and therefore should be clearly separated from it. No definite association between pleural epithelioid haemangioendothelioma and exposure to asbestos can be made from this small series but further investigation is warranted.