THERMOREGULATION IN THE COLD CHANGES DEPENDING ON THE TIME OF DAY AND FEEDING CONDITION: PHYSIOLOGICAL AND ANATOMICAL ANALYSES OF INVOLVED CIRCADIAN MECHANISMS
THERMOREGULATION IN THE COLD CHANGES DEPENDING ON THE TIME OF DAY AND FEEDING CONDITION: PHYSIOLOGICAL AND ANATOMICAL ANALYSES OF INVOLVED CIRCADIAN MECHANISMS
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DOI：
10.1016/j.neuroscience.2009.08.040
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发表时间：
2009-12-15
期刊：
影响因子：
3.3
通讯作者：
Nagashima, K.
中科院分区：
文献类型：
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作者：
Tokizawa, K.;Uchida, Y.;Nagashima, K.
体温（T-b）的昼夜节律是一种众所周知的现象。然而，它是未知的昼夜节律系统，包括视交叉上核（SCN）和时钟基因如何影响体温调节。在小鼠中的食物剥夺诱导T-b的更大的减少，特别是在光相。我们研究了关键时钟基因Clock和SCN在诱导低温过程中的作用。在20摄氏度禁食时，小鼠在黑暗阶段增加了代谢产热并维持了T-b，而在光照阶段，产热较少，导致体温过低。在这些条件下，SCN中的神经元活性，通过cFos表达评估，仅在光相中增加。然而，这种差异的温度调节和神经反应的阶段之间的时钟突变小鼠不太明显。SCN和室旁核之间的神经网络在低温中起重要作用。这些研究结果表明，昼夜节律系统本身是由两个饲养条件和环境温度的影响，它调节体温调节。(C)2009年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The circadian rhythm of body temperature (T-b) is a well-known phenomenon. However, it is unknown how the circadian system including the suprachiasmatic nucleus (SCN) and clock genes affects thermoregulation. Food deprivation in mice induces a greater reduction of T-b particularly in the light phase. We examined the role of Clock, one of key clock genes and the SCN during induced hypothermia. At 20 degrees C with fasting, mice increased their metabolic heat production in the dark phase and maintained T-b, whereas in the light phase, heat production was less, resulting in hypothermia. Under these conditions, neuronal activity in the SCN, assessed by cFos expression, increased only in the light phase. However, such differences in thermoregulatory and neural responses between the phases in Clock mutant mice were less marked. The neural network between the SCN and paraventricular nucleus appeared to be important in hypothermia. These findings suggest that the circadian system per se is influenced by both the feeding condition and environmental temperature and that it modulates thermoregulation. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.