DOPAMINE SYNAPTIC COMPLEX WITH PYRAMIDAL NEURONS IN PRIMATE CEREBRAL-CORTEX
DOPAMINE SYNAPTIC COMPLEX WITH PYRAMIDAL NEURONS IN PRIMATE CEREBRAL-CORTEX
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DOI：
10.1073/pnas.86.22.9015
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发表时间：
1989-11-01
影响因子：
11.1
通讯作者：
GEFFARD, M
中科院分区：
文献类型：
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作者：
GOLDMANRAKIC, PS;LERANTH, C;GEFFARD, M
多巴胺（DA）投射到大脑皮层被认为在认知过程中发挥重要作用。使用最近开发的单克隆抗血清直接针对DA和抗体直接againt酪氨酸羟化酶结合高尔基体浸渍和电子显微镜，我们观察到，DA和酪氨酸羟化酶传入建立对称的膜特化与索马，树突轴，并确定在前额叶，扣带和运动皮质的灵长类动物的锥体细胞的棘。的轴棘接触总是形成的突触复合体的一部分，其中的树突棘的锥体神经元是一个DA阳性对称和未标记的不对称终扣的目标。这种安排允许通过改变局部脊髓对兴奋性输入的反应来直接DA调制皮质投射神经元的整体兴奋性。
Dopamine (DA)-containing projections to the cerebral cortex are considered to play an important role in cognitive processes. Using a recently developed monoclonal antiserum directed against DA and an antibody directed againt tyrosin hydroxylase in combination with Golgi impregnation and electron microscopy, we have observed that DA and tyrosine hydroxylase afferents establish symmetric membrane specializations with the soma, dendritic shafts, and spines of identified pyramidal cells in the prefrontal, cingulate, and motor cortex of primates. The axospinous contacts invariably formed part of a synaptic complex in which the dentritic spine of a pyramidal neuron was the target of both a DA-positive symmetric and an unlabeled asymmetric bouton. This arrangement allows direct DA modulation of the overall excitability of cortical projection neurons by altering local spine response to excitatory inputs.