Cytoskeletal association of pp60src. The transforming protein of the Rous sarcoma virus.
Cytoskeletal association of pp60src. The transforming protein of the Rous sarcoma virus.
复制标题
pp60src 的细胞骨架关联。
DOI：
10.1016/0014-4827(87)90013-9
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发表时间：
1987
影响因子：
3.7
通讯作者：
Rohrschneider,L
中科院分区：
文献类型：
--
作者：
Henderson,D;Rohrschneider,L
免疫铁蛋白标记方法已被用于检测转化细胞耐洗涤剂细胞骨架中Rous肉瘤病毒（RSV）转化蛋白pp60src的分布。发现pp60src定位于粘附斑块中存在的肌动蛋白微丝，细胞间的粘附连接处以及微丝束。这种定位与一种假设是一致的，即转化的一些形态学效应是pp60src与微丝结合的靶蛋白在原位相互作用的结果。
Immunoferritin labelling methods have been employed to examine the distribution of the Rous Sarcoma virus (RSV)-transforming protein pp60srcin the detergent-resistant cytoskeleton of transformed cells. pp60srcwas found to be localized on actin microfilaments present in adhesion plaques, at adherens junctions between cells and also in microfilament bundles. This localization is consistent with the hypothesis that some of the morphological effects of transformation result from the interaction in situ of pp60srcwith microfilament-bound target proteins.