Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication.
Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication.
复制标题
DOI：
10.1111/j.1600-0773.1984.tb01916.x
复制
发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Leslie A. Shinobu;Shirley G. Jones;Mark M. Jones
中科院分区：
文献类型：
--
作者：
Leslie A. Shinobu;Shirley G. Jones;Mark M. Jones
本文报道了N-甲基-D-葡糖胺二硫代氨基甲酸钠盐和铵盐的合成及其作为镉中毒解毒剂的应用。该螯合剂对急性和反复接触镉中毒均有效。单次腹腔注射N-甲基-D-葡糖胺二硫代氨基甲酸钠（NaNMG-DTC），以大于1.1 mmol/kg体重的水平给药，可防止正常致死（大于95%）剂量的氯化镉（10 mg CdCl 2/kg体重），并导致随后镉离子的肝脏和肾脏负荷的剂量依赖性降低。在重复暴露镉中毒中，重复给予NaNMG-DTC可导致肾脏（71%）和肝脏（40%）镉水平大幅降低。未测定化合物的LD 50，但小鼠单次注射26.6 mmol/kg体重（注射液体积1.0 ml）耐受良好。
The sodium and ammonium salts of N-methyl-D-glucamine dithiocarbamate were prepared and their usefulness as antidotes for cadmium intoxication investigated. This chelating agent was found to be effective in both acute and repeated exposure cadmium poisoning. A single intraperitoneal injection of sodium N-methyl-D-glucamine dithiocarbamate (NaNMG-DTC), administered at a level greater than 1.1 mmol/kg body weight, protects against a normally lethal (greater than 95%) dose of cadmium chloride (10 mg CdCl2/kg body weight) and results in a subsequent dose-dependent decrease in the liver and kidney burdens of cadmium ion. In repeated exposure cadmium intoxication, repeated administration of NaNMG-DTC can result in substantial reductions in both the kidney (71%) and the liver (40%) levels of cadmium. The LD50 of the compound was not determined, but single injections of 26.6 mmol/kg body weight (injectate volume 1.0 ml) are well tolerated in mice.