The structure of the efflux pump AcrB in complex with bile acid
The structure of the efflux pump AcrB in complex with bile acid
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DOI：
10.1080/09687680802552257
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Beis, Konstantinos
中科院分区：
文献类型：
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作者：
Drew, David;Klepsch, Mirjam M.;Beis, Konstantinos
胃肠道细菌，如大肠杆菌，必须清除胆汁酸才能在肠道中生存。E.大肠杆菌中的AcrB主要由多药外排泵（multidrug efflux pump）介导。本文介绍了E. coliAcrB与脱氧胆酸盐复合物的分离度为3.85。所有证据表明，胆汁酸通过AcrAB-TolC复合物的周质前庭转运出细胞。
Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.