Role of attachment factors and attractants in fibroblast chemotaxis.
Role of attachment factors and attractants in fibroblast chemotaxis.
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附着因子和引诱剂在成纤维细胞趋化性中的作用。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
E. Schiffmann
中科院分区：
文献类型：
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作者：
Gauss;Kleinman Hk;Martin Gr;E. Schiffmann
成纤维细胞需要胶原基质和纤连蛋白用于粘附和随后在Boyden室中的迁移。纤连蛋白和淋巴因子都是良好的趋化因子，而胶原则较弱。成纤维细胞似乎需要细胞骨架组织和甲基化反应来进行趋化，这是先前巨噬细胞和中性粒细胞所显示的特性。然而，成纤维细胞比吞噬细胞迁移更慢，并且似乎需要蛋白质合成。
Fibroblasts require both a collagen substratum and fibronectin for adherence and subsequent migration in the Boyden chamber. Both fibronectin and lymphokines are good chemoattractants, whereas the collagens are weaker. Fibroblasts appear to require cytoskeletal organization and methylation reactions for chemotaxis, properties shown previously for macrophages and neutrophils. Fibroblasts, however, migrate more slowly than phagocytic cells and appear to require protein synthesis.