INDUCTION OF SALMONELLA STRESS PROTEINS UPON INFECTION OF MACROPHAGES
INDUCTION OF SALMONELLA STRESS PROTEINS UPON INFECTION OF MACROPHAGES
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DOI：
10.1126/science.1970672
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发表时间：
1990-05-11
期刊：
影响因子：
56.9
通讯作者：
HEFFRON, F
中科院分区：
文献类型：
--
作者：
BUCHMEIER, NA;HEFFRON, F
细菌基因的调节表达允许病原体适应宿主内的新环境条件。在巨噬细胞感染过程中，选择性地诱导30多种沙门氏菌蛋白的合成。沙门氏菌诱导的两种蛋白是热休克蛋白GroEL和DnaK。两个无毒的，巨噬细胞敏感的突变体沙门氏菌的大小GroEL和DnaK，但不能合成不同的亚群的蛋白质通常诱导的巨噬细胞内。选择性沙门氏菌蛋白的增强表达有助于细菌在巨噬细胞内的存活，也可能有助于热休克蛋白的明显免疫优势。
Regulated expression of bacterial genes allows a pathogen to adapt to new environmental conditions within the host. The synthesis of over 30Salmonellaproteins is selectively induced during infection of macrophages. Two proteins induced bySalmonellaare the heat shock proteins GroEL and DnaK. Two avirulent, macrophage-sensitive mutants ofSalmonellasynthesize GroEL and DnaK but fail to synthesize different subsets of proteins normally induced within the macrophage. Enhanced expression of selectedSalmonellaproteins contributes to bacterial survival within macrophages and may also contribute to the apparent immunodominance of heat shock proteins.