Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment.
Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment.
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DOI：
10.2174/157339411797642597
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发表时间：
2011-11
影响因子：
0.6
通讯作者：
Robins HI
中科院分区：
文献类型：
--
作者：
Leal T;Chang JE;Mehta M;Robins HI
随着肿瘤疾病治疗的治疗选择和支持性护理的改善，轻脑膜疾病的发病率也随之增加。在这篇综述中，临床表现，自然史，诊断评估和治疗方案，这种经常毁灭性的后遗症实体瘤，淋巴瘤和白血病将被总结。电离辐射、全身药物和鞘内药物的治疗效果将从现有文献中进行检查。此外，病理生理学在一定程度上定义了接近这一患者群体的治疗限制，为了帮助个体化的临床决策，将进行讨论。
As therapeutic options and supportive care for the treatment of neoplastic disease have improved, there has been an associated increase in the incidence of leptomeningeal disease. In this review, the clinical presentation, natural history, diagnostic evaluation, and treatment options for this often devastating sequela of solid tumors, lymphoma, and leukemia will be summarized. The therapeutic efficacy of ionizing radiation, systemic agents, and intrathecal drugs will be examined from the existing literature. Additionally the pathophysiology, which in part defines the therapeutic limitations in approaching this patient population, will be discussed in order to assist in individualized clinical decision making.