Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
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DOI：
10.1016/s0955-0674(00)00161-7
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发表时间：
2000-12-01
影响因子：
7.5
通讯作者：
Millet, S
中科院分区：
文献类型：
--
作者：
Joyner, AL;Liu, AM;Millet, S
十年前，鸡鹌鹑移植研究表明，中脑和后脑之间的连接具有组织中心的特性，能够形成中脑和小脑的模式。许多基因的功能模式，这些组织已被确定和广泛的研究。最近的实验表明，Otx2，Gbx2和Fgf8基因在这个组织中心的定位和功能中起着重要作用。
A decade ago, chick-quail transplantation studies demonstrated that the junction between the midbrain and hindbrain has the properties of an organizing center capable of patterning the midbrain and cerebellum. Many of the genes that function to pattern these tissues have been identified and extensively studied. Recent experiments have shown that Otx2, Gbx2 and Fgf8 genes play a major role in the positioning and functioning of this organizing center.