Combined simian hemorrhagic fever and Ebola virus infection in cynomolgus monkeys.
Combined simian hemorrhagic fever and Ebola virus infection in cynomolgus monkeys.
复制标题
食蟹猴合并猿猴出血热和埃博拉病毒感染。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
P. Jahrling
中科院分区：
文献类型：
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作者：
D. Dalgard;Hardy Rj;Pearson Sl;Pucak Gj;Quander Rv;Zack Pm;Clarence J. Peters;P. Jahrling
在最近进口的食蟹猴（Macaca fascicularis）中同时分离到猿猴出血热（SHF）病毒和一种新的埃博拉病毒株。埃博拉病毒以前从未在美国被分离出来，被认为对人类具有高致病性。报告按时间顺序列出了事件，包括为解决公众健康问题而采取的措施。该疾病的临床病理特征是突然厌食、脾肿大、乳酸脱氢酶、丙氨酸转氨酶和天冬氨酸转氨酶显著升高，血尿素氮、肌酐和其他血清化学参数升高不太显著。在组织学上，纤维蛋白沉积，出血，淋巴细胞和网状单核吞噬细胞的坏死存在于脾脏的SHF和埃博拉病毒感染的动物。血管内纤维蛋白血栓和出血也存在于肾髓质和胃肠道的多灶性。在胃肠道中偶尔观察到淋巴和上皮细胞坏死。被认为是埃博拉病毒感染特异性的组织病理学发现包括肝细胞坏死、肾上腺皮质肾小球坏死和间质性肺炎，所有这些通常与1至4 μ胞浆内嗜两性包涵体的存在相关。尽管停止了与动物的所有直接接触，但疾病仍在房间内传播，怀疑是飞沫或气溶胶传播。在动物处理者中产生了埃博拉病毒抗体，但没有发现临床疾病，这表明病毒的毒性较低。（250字处删节）
Simian hemorrhagic fever (SHF) virus and a new strain of Ebola virus were isolated concurrently in recently imported cynomolgus monkeys (Macaca fascicularis) being maintained in a quarantine facility. Ebola virus had never been isolated in the U.S. previously and was presumed to be highly pathogenic for humans. A chronology of events including measures taken to address the public health concerns is presented. The clinicopathologic features of the disease were abrupt anorexia, splenomegaly, marked elevations of lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase, with less prominent elevations of blood urea nitrogen, creatinine, and other serum chemistry parameters. Histologically, fibrin deposition, hemorrhage, and necrosis of lymphoid cells and reticular mononuclear phagocytes were present in the spleens of SHF and of Ebola virus-infected animals. Intravascular fibrin thrombi and hemorrhage were also present in the renal medulla and multifocally in the gastrointestinal tract. Necrosis of lymphoid and epithelial cells was occasionally noted in the gastrointestinal tract. The histopathologic findings considered specific for Ebola virus infection include hepatocellular necrosis, necrosis of the zona glomerulosa of the adrenal cortex, and interstitial pneumonia, all of which were generally associated with the presence of 1 to 4 mu intracytoplasmic amphophilic inclusion bodies. The disease spread within rooms despite discontinuation of all direct contact with animals, and droplet or aerosol transmission was suspected. Antibody to Ebola virus developed in animal handlers but no clinical disease was noted, suggesting a less virulent strain of virus.(ABSTRACT TRUNCATED AT 250 WORDS)