COMPLETE AMINO-ACID-SEQUENCE OF BOVINE THYMOSIN-BETA-4 - A THYMIC HORMONE THAT INDUCES TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE-ACTIVITY IN THYMOCYTE POPULATIONS
COMPLETE AMINO-ACID-SEQUENCE OF BOVINE THYMOSIN-BETA-4 - A THYMIC HORMONE THAT INDUCES TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE-ACTIVITY IN THYMOCYTE POPULATIONS
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DOI：
10.1073/pnas.78.2.1162
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
GOLDSTEIN, AL
中科院分区：
文献类型：
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作者：
LOW, TLK;HU, SK;GOLDSTEIN, AL
胸腺素的氨基酸序列。测定了从小牛胸腺中分离的多肽。胸腺素度量。4由43个氨基酸残基组成，分子量为4982，等电点为5.1。肽的NH2末端被乙酰基阻断。该分子在体内和体外诱导转移酶阴性小鼠胸腺细胞中末端脱氧核苷酸转移酶（DNA核苷酸转移酶，EC 2.7.7.31）的表达。似乎胸腺素。4作用于淋巴干细胞，并可能控制胸腺依赖淋巴细胞成熟过程的早期阶段。该肽是胸腺酶片段5中存在的几种肽之一，参与胸腺依赖性胸腺细胞的调节、分化和功能。
The amino acid sequence of thymosin .beta.4, a polypeptide isolated from calf thymus, was determined. Thymosin .beta.4 is composed of 43 amino acid residues and has a MW of 4982 and an isoelectric point of 5.1. The NH2 terminus of the peptide is blocked by an acetyl group. This molecule induces expression of terminal deoxynucleotidyl transferase (DNA nucleotidylexotransferase, EC 2.7.7.31) in transferase-negative murine thymocytes in vivo and in vitro. It appears that thymosin .beta.4 acts on lymphoid stem cells and may control the early stages of the maturation process of thymus-dependent lymphocytes. This peptide is one of several present in thymosin fraction 5 that participates in the regulation, differentiation, and function of thymus-dependent thymocytes.