Cardiovascular outcomes and all-cause mortality: Exploring the interaction between CKD and cardiovascular disease
Cardiovascular outcomes and all-cause mortality: Exploring the interaction between CKD and cardiovascular disease
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DOI：
10.1053/j.ajkd.2006.05.021
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发表时间：
2006-09-01
影响因子：
13.2
通讯作者：
Sarnak, Mark J.
中科院分区：
文献类型：
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作者：
Weiner, Daniel E.;Tabatabai, Sayed;Sarnak, Mark J.
背景：慢性肾脏疾病(CKD)是心血管疾病(CVD)的危险因素。同时，CVD可能促进CKD，导致恶性循环。我们通过探索CKD和CVD是否对未来的心血管和死亡率结果具有相加或协同作用来评估这一假说。方法：患者来自4项基于社区的研究：社区动脉粥样硬化风险、弗雷明翰心脏、弗雷明翰后代和心血管健康研究。CKD的定义是估计肾小球滤过率低于60毫升/分钟/1.73米(2)(
Background: Chronic kidney disease (CKD) is a risk factor for cardiovascular disease (CVD). Concurrently, CVD may promote CKD, resulting in a vicious cycle. We evaluated this hypothesis by exploring whether CKD and CVD have an additive or synergistic effect on future cardiovascular and mortality outcomes. Methods: Patients were pooled from 4 community-based studies: Atherosclerosis Risk in Communities, Framingham Heart, Framingham Offspring, and Cardiovascular Health Study. CKD is defined by an estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) (