COCAINE AS AN ABORTIVE AGENT IN CLUSTER HEADACHE
COCAINE AS AN ABORTIVE AGENT IN CLUSTER HEADACHE
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DOI：
10.1111/j.1526-4610.1982.hed2202069.x
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发表时间：
1982-01-01
期刊：
影响因子：
5
通讯作者：
BARRE, F
中科院分区：
文献类型：
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作者：
BARRE, F
盐酸可卡因[一种引起血管收缩的局部麻醉剂]作为丛集性头痛[人类]的流产治疗剂的系统试验。用舌下含服硝酸甘油（1.0 mg）进行头痛诱导，并使用可卡因进行流产。然后，受试者被指示在一种模式下，可卡因溶液的自我应用到他们的蝶腭孔区域流产。大多数患者可以通过在蝶腭孔区域应用可卡因溶液在15秒至3分钟内学会中止大多数丛集性头痛。在典型丛集性头痛持续的时间段（4-12周）内使用5-10%的溶液时，成瘾的风险很小，并且在停止伴随这种头痛的痛苦方面获益很大。当与患者教育计划相结合时，对丛集性头痛可能是一种有价值的预防性治疗措施。在某些情况下，它的快速有效性可能表明，大多数丛集性头痛的疼痛起源可能是在翼上颌窝区域。
A systematic trial of cocaine hydrochloride [a local anesthetic which causes vasoconstriction] as an abortive therapeutic agent in cluster headache [in humans] is presented. Headache induction was performed with sublingual nitroglycerin (1.0 mg) and cocaine was employed for abortive purposes. Subjects were then instructed in a mode of self-application of cocaine solution to their sphenopalatine foramen regions for abortion. Most patients can learn to abort most of their cluster headaches by application of cocaine solution to the sphenopalatine foramen region in from 15 s-3 min. The risk of addiction is slight when employing 5-10% solution for the period of time that the typical cluster persists (4-12 wk), and the benefits are great in cessation of the agonizing pain that accompanies this headache. Cocaine may be a valuable adjunctive abortive therapeutic measure in cluster headache when combined with a patient educational program. The rapidity of its effectiveness in some circumstances might suggest that the origin of much of the pain of cluster headache may be found in the pterygomaxillary fossa region.