Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue.
Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue.
复制标题
散斑对比光谱法，一种用于测量组织中微血管血流量的非侵入性漫射光学方法。
DOI：
10.1364/boe.5.002769
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发表时间：
2014-08-01
影响因子：
3.4
通讯作者：
Durduran T
中科院分区：
文献类型：
--
作者：
Valdes CP;Varma HM;Kristoffersen AK;Dragojevic T;Culver JP;Durduran T
我们介绍了一种新的无创漫射光学技术，散斑对比光谱学（SCOS），利用激光散斑对比的统计特性和点光源的光子扩散模型来探测深层组织血流。用液体幻影测试了该方法的可行性，证明了SCOS能够无创地测量浑浊介质的动态特性。我们进一步介绍了在人体前臂肌肉中使用SCOS进行两种模式的体内测量：一种依赖于源检测器分离的散斑对比度，另一种依赖于曝光时间。在这样做的过程中，我们还引入了对斑点对比度的关键校正，该校正考虑了镜头和传感器暗噪声的方差。
We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep tissue blood flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using liquid phantoms which demonstrate that SCOS is capable of measuring the dynamic properties of turbid media non-invasively. We further present an in vivo measurement in a human forearm muscle using SCOS in two modalities: one with the dependence of the speckle contrast on the source-detector separation and another on the exposure time. In doing so, we also introduce crucial corrections to the speckle contrast that account for the variance of the shot and sensor dark noises.