Human Cerebellar Sub-millimeter Diffusion Imaging Reveals the Motor and Non-motor Topography of the Dentate Nucleus
Human Cerebellar Sub-millimeter Diffusion Imaging Reveals the Motor and Non-motor Topography of the Dentate Nucleus
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DOI：
10.1093/cercor/bhw258
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发表时间：
2017-09-01
期刊：
影响因子：
3.7
通讯作者：
Villringer, A.
中科院分区：
文献类型：
--
作者：
Steele, C. J.;Anwander, A.;Villringer, A.
小脑对运动和认知行为的贡献背后的相互皮质-小脑回路形成了灵长类动物大脑中最大的系统之一。对非人类灵长类动物的研究表明，齿状核（小脑的主要输出核团）与运动区和非运动区都有不同的连接，但没有证据表明小脑皮质如何与人类的齿状核连接。在这里，我们使用在体内亚毫米波扩散成像的特点，这一基本组成部分的皮质小脑回路，并确定了一种模式的上级运动和下外侧非运动连接惊人的相似，提出了动物的工作。至关重要的是，我们还提出了第一个证据，表明在非人类灵长类动物中观察到的运动连接的优势可能在人类中显着减少-这一发现与在灵长类动物进化过程中小脑对高级认知行为的贡献增加是一致的。
The reciprocal cortico-cerebellar loops that underlie cerebellar contributions to motor and cognitive behavior form one of the largest systems in the primate brain. Work with non-human primates has shown that the dentate nucleus, the major output nucleus of the cerebellum, contains topographically distinct connections to both motor and non-motor regions, yet there is no evidence for how the cerebellar cortex connects to the dentate nuclei in humans. Here we used in-vivo submillimeter diffusion imaging to characterize this fundamental component of the cortico-cerebellar loop, and identified a pattern of superior motor and infero-lateral non-motor connectivity strikingly similar to that proposed by animal work. Crucially, we also present first evidence that the dominance for motor connectivity observed in non-human primates may be significantly reduced in man - a finding that is in accordance with the proposed increase in cerebellar contributions to higher cognitive behavior over the course of primate evolution.