IMMUNOGENICITY AND EFFICACY OF ORALLY-ADMINISTERED INACTIVATED INFLUENZA-VIRUS VACCINE IN MICE
IMMUNOGENICITY AND EFFICACY OF ORALLY-ADMINISTERED INACTIVATED INFLUENZA-VIRUS VACCINE IN MICE
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DOI：
10.1016/0264-410x(88)90222-8
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发表时间：
1988-06-01
期刊：
影响因子：
5.5
通讯作者：
SIX, HR
中科院分区：
文献类型：
--
作者：
FARAGMAHMOD, FI;WYDE, PR;SIX, HR
研究了福尔马林甲型/曼谷/79流感病毒灭活疫苗胶囊内、饮用水中和十二指肠内直接注射的免疫原性和保护效果。对所有这些方法的病毒特异性免疫球蛋白和免疫球蛋白A抗体反应均呈剂量依赖性，并因免疫条件不同而不同。用甲型/曼谷流感病毒活病毒鼻腔攻击小鼠后，饮水或胶囊中注射⩾66μg血凝素(HA)疫苗的小鼠和经十二指肠注射⩾0.66μg HA的小鼠鼻腔和肺部的病毒滴度均显著低于对照小鼠。
The immunogenicity and protective efficacy of formalin-inactivated whole influenza A/Bangkok/79 virus vaccine given to unprimed Swiss mice orally in capsules, in their drinking water, or by direct injection into the duodenum were studied. Virus-specific IgG and IgA antibody responses to all these methods were dose-dependent and varied according to immunization conditions. Following intranasal challenge with live A/Bangkok influenza virus, mice given ⩾66μg haemagglutinin (HA) of vaccine in drinking water or capsules, and mice injected into the duodenum with ⩾0.66μg HA, had significantly lower virus titres in their noses and lungs than control mice comparably inoculated.