Enantioselective synthesis of chiral alpha-aryl or alpha-alkyl substituted ethylphosphonates via Rh-catalyzed asymmetric hydrogenation with a P-stereogenic BoPhoz-type ligand.
Enantioselective synthesis of chiral alpha-aryl or alpha-alkyl substituted ethylphosphonates via Rh-catalyzed asymmetric hydrogenation with a P-stereogenic BoPhoz-type ligand.
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DOI：
10.1021/jo900417m
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Dao‐Yong Wang;Xiangping Hu;Jun Deng;Sai-Bo Yu;Zheng-chao Duan;Zhuo Zheng
中科院分区：
文献类型：
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作者：
Dao‐Yong Wang;Xiangping Hu;Jun Deng;Sai-Bo Yu;Zheng-chao Duan;Zhuo Zheng
在温和条件下，Rh催化的α，β-不饱和前体与β-立体异构体BoPhoz配体的不对称氢化反应，对映选择性地合成了光学活性的1-芳基或1-烷基取代的乙基膦酸酯，产物的ee值高达98%.
An enantioselective synthesis of optically active 1-aryl or 1-alkyl substituted ethylphosphonates, based on the first Rh-catalyzed asymmetric hydrogenation of corresponding alpha,beta-unsaturated precursors with a P-stereogenic BoPhoz-type ligand under the mild condition, was developed, in which a wide range of 1-aryl or 1-alkyl substituted ethylphosphonates were achieved in up to 98% ee.