Neural mediators of changes of mind about perceptual decisions.

Neural mediators of changes of mind about perceptual decisions.
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DOI:
10.1038/s41593-018-0104-6
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发表时间:
2018-04
影响因子:
25
通讯作者:
Daw ND
Daw ND
中科院分区:
医学1区
文献类型:
--
作者:
Fleming SM;van der Putten EJ;Daw ND

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根据新证据改变想法是认知灵活性的标志。为了修正我们对之前决策的信心,应该使用新的证据来更新关于选择准确性的信念,但这个过程在人脑中如何展开仍然未知。在这里,我们操纵额外的感官证据是否支持或否定先前的运动方向辨别判断,同时使用功能磁共振成像记录人脑中的神经活动标记。在后内侧额叶皮层 (pMFC) 的活动中选择性地观察到决策后证据的特征(正确对数赔率的变化)。相比之下,前额叶皮层(aPFC)的不同活动特征介导了决策后证据对主观信心的影响,与决策价值的变化无关。我们的研究结果共同揭示了人脑决策后思维变化的候选神经调节因子,并指出了改善认知灵活性缺陷的可能目标。
Changing one’s mind on the basis of new evidence is a hallmark of cognitive flexibility. To revise our confidence in a previous decision, new evidence should be used to update beliefs about choice accuracy, but how this process unfolds in the human brain remains unknown. Here we manipulated whether additional sensory evidence supports or negates a previous motion direction discrimination judgment while recording markers of neural activity in the human brain using fMRI. A signature of post-decision evidence (change in log-odds correct) was selectively observed in the activity of posterior medial frontal cortex (pMFC). In contrast, distinct activity profiles in anterior prefrontal cortex (aPFC) mediated the impact of post-decision evidence on subjective confidence, independently of changes in decision value. Together our findings reveal candidate neural mediators of post-decisional changes of mind in the human brain, and indicate possible targets for ameliorating deficits in cognitive flexibility.
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