Change in MS-related disability in a population-based cohort - A 10-year follow-up study
Change in MS-related disability in a population-based cohort - A 10-year follow-up study
复制标题
DOI：
10.1212/01.wnl.0000101724.93433.00
复制
发表时间：
2004-01-13
期刊：
影响因子：
9.9
通讯作者：
Rodriguez, M
中科院分区：
文献类型：
--
作者：
Pittock, SJ;Mayr, WT;Rodriguez, M
目的：研究构成1991年明尼苏达州奥姆斯特德县多发性硬化（MS）患病率队列的个体患者10年内残疾的变化。方法：作者在2001年重新评估了1991年的队列。作者确定了每名仍活着的患者以及死亡患者在死亡前一年内的扩展残疾状态量表评分（EDSS）。作者分析了残疾变化的潜在预后意义的决定因素。结果：1991年队列的162例患者中有161例获得了随访信息。只有15%的患者接受了免疫调节治疗。整个队列10年内EDSS的平均变化为1分，20%恶化大于或等于2分。对于EDSS患者
Objectives: To study the change in disability over 10 years in individual patients constituting the 1991 Olmsted County, MN, multiple sclerosis (MS) prevalence cohort. Methods: The authors reassessed this 1991 cohort in 2001. The authors determined the Expanded Disability Status Scale scores (EDSS) for each patient still alive, and within the year prior to death for those who died. The authors analyzed determinants of potential prognostic significance on change in disability. Results: Follow-up information was available for 161 of 162 patients in the 1991 cohort. Only 15% had received immunomodulatory therapy. The mean change in EDSS for the entire cohort over 10 years was 1 point and 20% worsened by greater than or equal to2 points. For patients with EDSS