A CMOS Front-End With Integrated Magnetoresistive Sensors for Biomolecular Recognition Detection Applications
A CMOS Front-End With Integrated Magnetoresistive Sensors for Biomolecular Recognition Detection Applications
复制标题
集成磁阻传感器的CMOS前端生物分子识别检测应用
DOI：
10.1109/tbcas.2017.2743685
复制
发表时间：
2017-10-01
影响因子：
5.1
通讯作者：
Piedade, Moises S.
中科院分区：
文献类型：
--
作者：
Costa, Tiago;Cardoso, Filipe A.;Piedade, Moises S.
巨磁阻（GMR）传感器的发展在纳米医学中表现出显着的优势，特别是对于超灵敏的即时诊断。为此，要求检测系统在保持最大信噪比的同时是紧凑的、便携的和低功耗的。本文报道了一种用于生物分子识别检测的集成磁阻传感器的CMOS前端。基于GMR传感器信号和噪声的表征，CMOS构建块（即，电流源、多路复用器和ADC）的设计目标是与GMR传感器的噪声相比可以忽略不计的噪声和低功耗。CMOS前端采用AMS 0.35 μ m工艺制造，磁阻传感器在CMOS芯片上进行后加工，成品率高（97.9%）。由于其低电路噪声（16 nV/root Hz）和整体等效磁噪声（11.5 nT/root Hz），整个系统能够检测250 nm磁性纳米颗粒，电路施加的信噪比退化仅为-1.4 dB。此外，所提出的解决方案的低功耗（6.5 mW）和小尺寸（7.59 mm（2））保证了检测系统的便携性，允许其在护理点使用。
The development of giant magnetoresistive (GMR) sensors has demonstrated significant advantages in nanomedicine, particularly for ultrasensitive point-of-care diagnostics. To this end, the detection system is required to be compact, portable, and low power consuming at the same time that a maximum signal to noise ratio is maintained. This paper reports a CMOS front-end with integrated magnetoresistive sensors for biomolecular recognition detection applications. Based on the characterization of the GMR sensor's signal and noise, CMOS building blocks (i.e., current source, multiplexers, and preamplifier) were designed targeting a negligible noise when compared with the GMR sensor's noise and a low power consumption. The CMOS front-end was fabricated using AMS 0.35 mu m technology and the magnetoresistive sensors were post-fabricated on top of the CMOS chip with high yield (97.9%). Due to its low circuit noise (16 nV/root Hz) and overall equivalent magnetic noise (11.5 nT/root Hz), the full system was able to detect 250 nm magnetic nanoparticles with a circuit imposed signal-to-noise ratio degradation of only -1.4 dB. Furthermore, the low power consumption (6.5 mW) and small dimensions (7.59 mm(2)) of the presented solution guarantees the portability of the detection system allowing its usage at the point-of-care.