Biocompatible and Nanoenabled Technologies for Biological Modulation
Biocompatible and Nanoenabled Technologies for Biological Modulation
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DOI：
10.1002/admt.202100216
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发表时间：
2021-06
影响因子：
6.8
通讯作者：
E. Ostroff;Kavita Parekh;Aleksander Prominski;B. Tian
中科院分区：
文献类型：
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作者：
E. Ostroff;Kavita Parekh;Aleksander Prominski;B. Tian
用于细胞和组织生物调节的生物相容性纳米级设备具有对医疗和工业技术产生巨大影响的潜力。典型的医疗设备和疗法往往是宏观规模的，由非生物相容性材料组成，并且目标广泛，导致治疗不精确和副作用，例如慢性免疫反应和组织损伤。纳米和生物相容性技术的发展——从用于局部药物输送的可生物降解纳米颗粒到用于刺激治疗的瞬态电子设备，再到应用于纳米医学的工程生物膜——将继续推动个性化医疗和精准治疗的出现。在这篇综述中，回顾了这一领域的最新研究，首先分析了纳米技术和生物相容性技术的合成，然后提出了有关此类材料开发的重要考虑因素。最后，研究了生物相容性纳米设备的最新进展，然后讨论了该领域未来的研究方向。
Biocompatible and nanoscale devices for biological modulation of cells and tissues possess the potential for tremendous impact on medical and industrial technologies. Typical medical devices and therapies tend to be macroscale, comprised of nonbiocompatible materials, and broadly targeted, resulting in imprecise treatments and adverse effects such as chronic immune response and tissue damage. The development of nanoenabled and biocompatible technologies—ranging from biodegradable nanoparticles for localized drug delivery to transient electronic devices for stimulation therapy to engineered biofilms with applications to nanomedicine—will continue to enable the advent of personalized medicine and precision therapies. In this review, recent research into this frontier is reviewed, first analyzing the synthesis of nanoenabled and biocompatible technologies and then presenting significant considerations regarding the development of such materials. Lastly, the latest advancements in biocompatible, nanoenabled devices are examined, followed by a discussion of the direction of future research in the field.