Association Between Vitamin D Status and Physical Function in the Severely Obese
Association Between Vitamin D Status and Physical Function in the Severely Obese
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DOI：
10.1210/jc.2014-1704
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发表时间：
2014-07-01
影响因子：
5.8
通讯作者：
O'Shea, D.
中科院分区：
文献类型：
--
作者：
Ahern, T.;Khattak, A.;O'Shea, D.
背景：严重肥胖受试者(身体质量指数[BMI]和GT；40 kg/m(2))的死亡率比健康BMI受试者高85%；身体机能差可能是原因之一。维生素D缺乏症在肥胖者中很常见，并与老年人的身体功能障碍有关。目的：我们确定了严重肥胖者维生素D状况与身体功能的关系。设计、设置和患者：我们对严重肥胖者进行了一项基于临床的横断面研究。根据医学研究所维生素D状况分类，参与者被分成三组。主要观察指标：我们比较了自我报告的活动水平以及步行500米和上下17厘米台阶50次所需的时间。结果：我们招募了252名受试者(年龄43.7±11.2岁；体重指数50.7+/-9.7 kg/m(2))；25-羟基维生素D(25OHD)浓度<30nmol/L。25OHD>；50nmol/L的参与者，与25OHD的参与者相比
Context: Mortality is 85% higher in severely obese subjects (body mass index [BMI] >40 kg/m(2)) than in subjects with a healthy BMI; poor physical function may be contributory. Hypovitaminosis D is common in obese subjects and is associated with physical dysfunction in the elderly.Objective: We determined the relationship between vitamin D status and physical function in severely obese subjects.Design, Setting, and Patients: We conducted a clinic-based, cross-sectional study of severely obese subjects. Participants were stratified into three groups according to the Institute of Medicine (IOM) vitamin D status categorization.Main Outcome Measures: We compared levels of self-reported activity and times taken to walk 500 m and to ascend and descend a 17-cm step 50 times.Results: We recruited 252 subjects (age, 43.7 +/- 11.2 y; BMI, 50.7 +/- 9.7 kg/m(2)); 25-hydroxyvitamin D (25OHD) concentrations were less than 30 nmol/L in 109 participants. Participants with a 25OHD >50 nmol/L, compared to those with a 25OHD