Rab Proteins and the Compartmentalization of the Endosomal System
Rab Proteins and the Compartmentalization of the Endosomal System
复制标题
DOI：
10.1101/cshperspect.a022616
复制
发表时间：
2014-11-01
影响因子：
7.2
通讯作者：
Zerial, Marino
中科院分区：
文献类型：
--
作者：
Wandinger-Ness, Angela;Zerial, Marino
在大约70种人Rab GTP酶中，近四分之三参与内吞运输。内体膜转运途径的显著可塑性与受体信号传导和Rab GTP酶调节的支架密切相关。在这里，我们回顾了目前的文献有关内吞Rab GTdR定位，功能和协调与调节蛋白和效应。Rab GTP酶在以下方面的作用进行了讨论：（1）将内吞途径划分为早期、再循环、晚期和溶酶体途径;（2）协调从囊泡出芽到融合的各个运输步骤;（3）效应相互作用组;（4）整合GTP酶和信号级联。
Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is closely coupled to receptor signaling and Rab GTPase-regulated scaffolds. Here we review current literature pertaining to endocytic Rab GTPase localizations, functions, and coordination with regulatory proteins and effectors. The roles of Rab GTPases in (1) compartmentalization of the endocytic pathway into early, recycling, late, and lysosomal routes; (2) coordination of individual transport steps from vesicle budding to fusion; (3) effector interactomes; and (4) integration of GTPase and signaling cascades are discussed.