Alteration of cytokine profiles in uranium miners exposed to long-term low dose ionizing radiation.
Alteration of cytokine profiles in uranium miners exposed to long-term low dose ionizing radiation.
复制标题
暴露于长期低剂量电离辐射的铀矿工中细胞因子谱的改变。
DOI：
10.1155/2014/216408
复制
发表时间：
2014
影响因子：
--
通讯作者：
Sun Q
中科院分区：
文献类型：
--
作者：
Li K;Chen Y;Li X;Lei S;Chen Q;Liu J;Sun Q
Objective. The aim of the study is to estimate the immune function through cytokine profiles in sera of uranium mines. Methods. Antibody arrays were used to detect 50 cytokines in sera of uranium miners. Miners who had continuously worked underground for <5 years were treated as control group and those who worked for ⩾5 years as experimental group. Results. Of 28 measurable cytokines, the release of IL-1α, IL-1RI, IL-15, IL-3, and IP-10 were significantly upregulated in the experimental group, and no cytokine was found significantly downregulated. Other proinflammatory cytokines such as IFN-γ, IL-10, IL-6, and TNFα levels were slightly upregulated in the experimental group. With adjustment to age, BMI, and cigarette smoking, IL-1α and IL-3 levels increased significantly with underground time. Conclusion. Alteration of cytokine profiles in this study may indicate persistent inflammatory responses in uranium miners exposed to long-term low doses radiation.
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影响因子：
3.8
作者：
Gazin, V;Kerdine, S;Raoul, H
通讯作者：
Raoul, H
影响因子：
4.5
作者：
Lourenco, J.;Pereira, R.;Mendo, S.
通讯作者：
Mendo, S.
影响因子：
2.6
作者：
YARILIN, AA;BELYAKOV, IM;GNEZDITSKAYA, EV
通讯作者：
GNEZDITSKAYA, EV
影响因子：
3
作者：
Liu SZ;Jin SZ;Liu XD;Sun YM
通讯作者：
Sun YM
DOI：
10.1111/j.1365-2249.1997.272-ce1158.x
发表时间：
1997-02-01
影响因子：
4.6
作者：
Harrington，NP;Chambers，KA;Filion，LG
通讯作者：
Filion，LG