Risk factors associated with the development of interstitial lung abnormalities
Risk factors associated with the development of interstitial lung abnormalities
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DOI：
10.1183/13993003.03005-2020
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发表时间：
2021-08-01
影响因子：
24.3
通讯作者：
Selman, Moises
中科院分区：
文献类型：
--
作者：
Buendia-Roldan, Ivette;Fernandez, Rosario;Selman, Moises
背景：在50岁以上的人群中，约有8%-10%的人存在间质性肺异常(ILAs)，但其危险因素尚不确定。方法从墨西哥国家呼吸疾病研究所的817名受试者中，80人(9.7%)表现为间质性肺异常，并与564名相同队列的正常高分辨率CT患者进行比较，以评估人口统计学和功能差异，并与从同一队列中随机选择的80名患者进行生物标志物的比较。检测MUC5B突变体rs35705950、端粒长度、血清基质金属蛋白酶(MMP1、MMP2、MMP3、MMP7、MMP8、MMP9、MMP12、MMP13、白介素6、表面活性蛋白(SP)D、α-Klotho和抵抗素)水平。
Background Around 8-10% of individuals over 50 years of age present interstitial lung abnormalities (ILAs), but their risk factors are uncertain.Methods From 817 individuals recruited in our lung ageing programme at the Mexican National Institute of Respiratory Diseases, 80 (9.7%) showed ILAs and were compared with 564 individuals of the same cohort with normal high-resolution computed tomography to evaluate demographic and functional differences, and with 80 individuals randomly selected from the same cohort for biomarkers. We evaluated MUC5B variant rs35705950, telomere length, and serum levels of matrix metalloproteinase (MMP)-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, interleukin (IL)-6, surfactant protein (SP)-D, alpha-Klotho and resistin.Results Individuals with ILAs were usually males (p