Non-targeted hepatitis C virus screening in acute care healthcare settings in the Southern Appalachian region.
Non-targeted hepatitis C virus screening in acute care healthcare settings in the Southern Appalachian region.
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DOI：
10.1002/emp2.12819
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发表时间：
2022-10
影响因子：
2.3
通讯作者：
中科院分区：
文献类型：
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作者：
本研究的目的是评价急诊科（ED）和其他医疗机构在确定为HCV感染并与HCV护理相关的患者中进行非靶向丙型肝炎病毒（HCV）筛查的性能。在美国南阿巴拉契亚地区，我们在不同医疗环境的10个机构（包括急诊室、门诊和住院单位）开发了非靶向HCV筛查和联系护理计划。对血清样本进行HCV抗体检测，如果阳性，则进行HCV核糖核酸（RNA）检测，作为活动性感染的确证性检测。与RNA检测阳性的患者联系，将他们与HCV护理联系起来。在2017年至2019年期间，在195，152名接受HCV感染筛查的患者中，抗体检测阳性10139例，占8.5%，（5.2%的筛查患者和61.3%的抗体检测阳性患者）通过RNA检测呈阳性，5778例（筛查患者的3.0%和RNA检测阳性患者的57.0%）成功与HCV治疗联系起来。在ED筛查的83,645例患者中，HCV抗体阳性9060例（10.8%），RNA检测阳性5243例（6.3%）。在RNA检测阳性的患者中，艾德筛查的患者（44.1%）与门诊（67.6%）（P < 0.01）和住院单位（50.9%）（P < 0.01）相比，与护理的联系较低。在急性护理环境中进行非靶向HCV筛查可以识别大量HCV感染者。为了优化这些筛查项目的效用，未来的工作需要制定最佳实践，始终将这些患者与HCV护理联系起来。
The objective of this study was to evaluate the performance of non‐targeted hepatitis C virus (HCV) screening in emergency departments (EDs) and other healthcare settings in terms of patients identified with HCV infection and linked to HCV care. In the Southern Appalachian region of the United States, we developed non‐targeted HCV screening and linkage‐to‐care programs in 10 institutions at different healthcare settings, including EDs, outpatient clinics, and inpatient units. Serum samples were tested for HCV antibodies, and if positive, reflexed to HCV ribonucleic acid (RNA) testing as a confirmatory test for active infection. Patients with positive RNA tests were contacted to link them to HCV care. Between 2017 and 2019, among 195,152 patients screened for HCV infection, 16,529 (8.5%) were positive by antibody testing, 10,139 (5.2% of screened patients and 61.3% of patients positive by antibody test) were positive by RNA testing, and 5778 (3.0% of screened patients and 57.0% of patients positive by RNA test) were successfully linked to HCV care. Among 83,645 patients screened in EDs, 9060 (10.8%) were positive by HCV antibody, and 5243 (6.3%) were positive by RNA test. Among patients positive by RNA testing, linkage to care was lower for patients screened in the ED (44.1%) compared with outpatient clinics (67.6%) (P < 0.01) and inpatient units (50.9%) (P < 0.01). Non‐targeted HCV screening in acute care settings can identify large numbers of people with HCV infection. To optimize the utility of these screening programs, future work is needed to develop best practices that consistently link these patients to HCV care.
影响因子：
2.5
作者：
通讯作者：
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影响因子：
4.2
作者：
Daniel Moore J;Galbraith J;Humphries R;Havens JR
通讯作者：
Havens JR