Cardiac telocytes exist in the adult Xenopus tropicalis heart.
Cardiac telocytes exist in the adult Xenopus tropicalis heart.
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心脏远程细胞存在于成年热带爪蟾的心脏中。
DOI：
10.1111/jcmm.14947
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发表时间：
2020
影响因子：
5.3
通讯作者：
Cai Dongqing
中科院分区：
文献类型：
--
作者：
Lv Luocheng;Liao Zhaofu;Luo Jiali;Chen Hongyi;Guo Hongyan;Yang Jifeng;Huang Ruijin;Pu Qin;Zhao Hui;Yuan Ziqiang;Feng Shanshan;Qi Xufeng;Cai Dongqing
最近的研究表明，心脏端细胞（CTs）在心脏病理生理和损伤心肌的再生中起着重要作用。最近，我们报道了成年热带爪蟾的心脏可以通过根尖切除术在损伤后以几乎无疤痕的方式完美再生。然而，端细胞是否存在于热带爪蟾心脏，并在损伤的热带爪蟾心肌再生的影响仍然是未知的。超微结构和免疫荧光双重染色结果清楚地表明，在热带田鼠心肌中存在CT。热带香鱼心肌中的CT主要分布在心肌细胞小梁的表面周围，并通过端足末端之间的纳米接触连接，形成三维网络。CT可能在损伤心肌的再生中起一定作用。
Recent research has revealed that cardiac telocytes (CTs) play an important role in cardiac physiopathology and the regeneration of injured myocardium. Recently, we reported that the adultXenopus tropicalisheart can regenerate perfectly in a nearly scar‐free manner after injury via apical resection. However, whether telocytes exist in theX tropicalisheart and are affected in the regeneration of injuredX tropicalismyocardium is still unknown. The present ultrastructural and immunofluorescent double staining results clearly showed that CTs exist in theX tropicalismyocardium. CTs in theX tropicalismyocardium were mainly twined around the surface of cardiomyocyte trabeculae and linked via nanocontacts between the ends of the telopodes, forming a three‐dimensional network. CTs might play a role in the regeneration of injured myocardium.