Seroprevalence of hepatitis B virus and hepatitis C virus co-infection among people living with HIV/AIDS visiting antiretroviral therapy centres in Nepal: a first nationally representative study
Seroprevalence of hepatitis B virus and hepatitis C virus co-infection among people living with HIV/AIDS visiting antiretroviral therapy centres in Nepal: a first nationally representative study
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DOI：
10.1016/j.ijid.2017.04.011
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发表时间：
2017-07-01
影响因子：
8.4
通讯作者：
Dixit, S.
中科院分区：
文献类型：
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作者：
Ionita, G.;Malviya, A.;Dixit, S.
目的：为了评估人类免疫缺陷病毒（HIV），丙型肝炎病毒（HCV），和B型肝炎病毒（HBV）合并感染的人与艾滋病病毒（PLHIV.Methods）在尼泊尔的流行情况：677 PLHIV代表的主要受影响的人群（KAP）在尼泊尔，谁正在接受抗逆转录病毒（ART）治疗在全国各地的ART诊所，自愿参加了这项研究。进行了基于试剂盒的快速检测，然后进行ELISA验证，重点是HBV表面抗原（HBsAg）和抗HCV抗体（抗HCV）。结果：在677例PLHIV患者中，HBV和HCV合并感染的发生率分别为19%（95%CI 16.6-22.7%）和4.4%（95%CI 3.1-6.6%）。东部地区的HCV感染率最高（48%）。合并感染率最高的年龄组是30-39岁（HCV和HBV合并感染分别为58%和70%）。在调整混杂因素后，男性比女性更容易合并HBV感染（调整后的比值比（AOR）4.61，95%CI 1.42-14.98）。同样，男性艾滋病毒感染者（AOR 5.7，95% CI 2.06-15.98），具有中等教育水平（AOR 3.04，95% CI 1.06-8.70），或吸毒者（AOR 28.7，95%CI 14.9-55.22），HCV合并感染的可能性显著增加。这是有史以来第一次对尼泊尔艾滋病毒感染者进行的艾滋病毒、乙型肝炎病毒和丙型肝炎病毒合并感染的国家评估，表明丙型肝炎病毒和乙型肝炎病毒感染对这一人群构成健康威胁，需要采取干预措施减轻合并感染的影响，防止进一步的发病率和死亡率。(C)2017作者（S）由Elsevier Ltd代表国际传染病学会出版。这是一个在CC BY-NC-ND许可下的开放获取文章
Objectives: To assess the prevalence of human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) co-infections among people living with HIV (PLHIV) in Nepal.Methods: A sample of 677 PLHIV representing key affected populations (KAP) in Nepal, who were undergoing antiretroviral (ART) therapy in ART clinics around the country, were voluntarily enrolled in the study. Rapid kit-based testing followed by ELISA for validation was performed, focusing on HBV surface antigen (HBsAg) and antibodies against HCV (anti-HCV). A multivariate logistic regression model was used to identify factors associated with HBV and HCV co-infection.Results: HCV and HBV co-infection among the 677 PLHIV was found to be 19% (95% confidence interval (CI) 16.6-22.7%) and 4.4% (95% CI 3.1-6.6%), respectively. The Eastern Region had the highest percentage of HCV infection (48%). The age group with the highest rates of co-infection was 30-39 years (58% and 70%, respectively, for HCV and HBV co-infection). After adjusting for confounding, males were more likely to have HBV co-infection than females (adjusted odds ratio (AOR) 4.61, 95% CI 1.42-14.98). Similarly, PLHIV who were male (AOR 5.7, 95% CI 2.06-15.98), had a secondary level of education (AOR 3.04, 95% CI 1.06-8.70), or who were drug users (AOR 28.7, 95% CI 14.9-55.22) were significantly more likely to have HCV co-infection.Conclusion: This first ever national assessment of HIV, HBV, and HCV co-infection performed among PLHIV in Nepal demonstrates that HCV and HBV infections are a health threat to this population and that interventions are required to mitigate the effects of co-infection and to prevent further morbidity and mortality. (C) 2017 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license