In vivo characterization of the inflammatory properties of poly(tetrafluoroethylene) particulates.
In vivo characterization of the inflammatory properties of poly(tetrafluoroethylene) particulates.
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聚（四氟乙烯）颗粒炎症特性的体内表征。
DOI：
10.1002/jbm.820251009
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
E. Berg
中科院分区：
文献类型：
--
作者：
N. Kossovsky;D. Millett;S. Juma;N. Little;P. C. Briggs;S. Raz;E. Berg
上皮下注射微粒聚（PTFE）正在成为一种广泛接受的治疗许多泌尿系统疾病。由于对注射部位的长期组织学形态知之甚少，因此进行了本动物研究。三个群体，每个群体由两只杂种犬、五只新西兰白色兔和10只BALB/c小鼠组成，注射甘油载体中的聚（丙）颗粒（Polytef糊剂），并随访1周、3个月、6个月和1年。小鼠各接受一次背部皮下注射，家兔各接受两次乳晕下注射，犬各接受三次乳晕下注射以及两次尿道周围注射。活检部位的组织学检查显示持续的慢性炎症反应，伴随受累组织体积的进行性增长。除巨细胞和巨噬细胞外，淋巴细胞在3个月时变得明显，1年时占细胞浸润的40%。在兔模型中，在1年期间也观察到浆细胞。注射PTFE引起的炎性假瘤的进行性生长可能会损害某些涉及颗粒PTFE的泌尿外科手术的长期安全性。
Suburothelial injections of particulate poly(tetrafluoroethylene) (PTFE) is becoming a widely accepted treatment for a number of urological disorders. Because little is known about the long-term histologic morphology of the injection site, this animal study was performed. Three populations, each consisting of two mongrel dogs, five New Zealand White rabbits, and 10 BALB/c mice, were injected with poly(tetrafluoroethylene) particulate in a glycerine carrier (Polytef Paste) and were followed for a period of 1 week, 3 months, 6 months, and 1 year. Mice received one subcutaneous dorsal injection each, rabbits received two subareolar injections each, and dogs received three subareolar injections each in addition to two periurethral injections. Histologic examination of the biopsy sites revealed a persistent chronic inflammatory reaction with progressive growth of the involved tissue volume. In addition to giant cells and macrophages, lymphocytes became apparent at 3 months and constituted up to 40% of the cellular infiltrate by 1 year. Plasma cells were also noted at the 1-year period in the rabbit model. The progressive growth of the inflammatory pseudo-tumors evoked by injected PTFE may compromise the long-term safety of certain urological procedures involving particulate PTFE.