Pathogenesis of HIV in the gastrointestinal tract.
Pathogenesis of HIV in the gastrointestinal tract.
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DOI：
10.1007/s11904-007-0002-0
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发表时间：
2007-02-01
影响因子：
4.6
通讯作者：
Dandekar, Satya
中科院分区：
文献类型：
--
作者：
Dandekar, Satya
肠道相关淋巴组织（GALT）是HIV早期复制和严重CD4+ T细胞耗竭的重要部位。启动高活性抗逆转录病毒治疗导致病毒复制的不完全抑制和GALT中的CD4+ T细胞与外周血相比显著延迟且仅部分恢复。GALT中持续的病毒复制导致病毒库的补充和维持。炎症水平升高、免疫激活以及粘膜修复和再生水平降低导致肠病。对肠道黏膜免疫系统的评估将为更好地了解高效抗逆转录病毒治疗在免疫恢复和抑制病毒宿主方面的疗效提供更好的见解。
Gut-associated lymphoid tissue (GALT) is an important site for early HIV replication and severe CD4+ T-cell depletion. Initiation of highly active antiretroviral therapy leads to incomplete suppression of viral replication and substantially delayed and only partial restoration of CD4+ T cells in GALT compared with peripheral blood. Persistent viral replication in GALT leads to replenishment and maintenance of viral reservoirs. Increased levels of inflammation, immune activation, and decreased levels of mucosal repair and regeneration contribute to enteropathy. Assessment of gut mucosal immune system will provide better insights into the efficacy of highly active antiretroviral therapy in immune restoration and suppression of viral reservoirs.