Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: An event-related fMRI study
Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: An event-related fMRI study
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DOI：
10.1176/appi.ajp.158.9.1423
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发表时间：
2001-09-01
影响因子：
17.7
通讯作者：
Stenger, VA
中科院分区：
文献类型：
--
作者：
Carter, CS;MacDonald, AW;Stenger, VA
目的：研究精神分裂症患者与内部操作监控相关的脑活动，以检验精神分裂症患者前扣带回错误相关活动受损的假说。方法：对17例精神分裂症患者和16名健康对照受试者在连续操作任务中进行事件相关功能磁共振成像；使用刺激降解来增加错误率。结果：对照组患者前扣带回皮质有错误相关活动，但精神分裂症患者没有，两组脑活动差异显著。患者在错误委托后的反应时减慢也较少。结论：错误委托后前扣带回较低的错误相关活动和较少的操作调整与前扣带回功能障碍与执行功能的一个评估成分--执行功能的内部监控的具体变化有关的假设是一致的。
Objective: The authors examined brain activity associated with the internal monitoring of performance to test the hypothesis that error-related activity in the anterior cingulate cortex is impaired in patients with schizophrenia.Method: Seventeen patients with schizophrenia and 16 healthy comparison subjects underwent event-related functional magnetic resonance imaging during a continuous performance task; stimulus degradation was used to increase error rates.Results: Comparison subjects, but not schizophrenic patients, showed error-related activity in the anterior cingulate cortex, and this difference in brain activity was significantly different across the two groups. Patients also showed less slowing of reaction time after error commission.Conclusions: Lower error-related activity in the anterior cingulate cortex and less performance adjustment after error commission are consistent with the hypothesis that disturbances in anterior cingulate cortex function are related to a specific alteration in an evaluative component of executive functioning-the internal monitoring of performance.