Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project.
Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project.
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DOI：
10.1017/thg.2015.57
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发表时间：
2015-10
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通讯作者：
Silventoinen K
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Jelenkovic A;Yokoyama Y;Sund R;Honda C;Bogl LH;Aaltonen S;Ji F;Ning F;Pang Z;Ordoñana JR;Sánchez-Romera JF;Colodro-Conde L;Burt SA;Klump KL;Medland SE;Montgomery GW;Kandler C;McAdams TA;Eley TC;Gregory AM;Saudino KJ;Dubois L;Boivin M;Tarnoki AD;Tarnoki DL;Haworth CM;Plomin R;Öncel SY;Aliev F;Stazi MA;Fagnani C;D'Ippolito C;Craig JM;Saffery R;Siribaddana SH;Hotopf M;Sumathipala A;Rijsdijk F;Spector T;Mangino M;Lachance G;Gatz M;Butler DA;Bayasgalan G;Narandalai D;Freitas DL;Maia JA;Harden KP;Tucker-Drob EM;Kim B;Chong Y;Hong C;Shin HJ;Christensen K;Skytthe A;Kyvik KO;Derom CA;Vlietinck RF;Loos RJ;Cozen W;Hwang AE;Mack TM;He M;Ding X;Chang B;Silberg JL;Eaves LJ;Maes HH;Cutler TL;Hopper JL;Aujard K;Magnusson PK;Pedersen NL;Aslan AK;Song YM;Yang S;Lee K;Baker LA;Tuvblad C;Bjerregaard-Andersen M;Beck-Nielsen H;Sodemann M;Heikkilä K;Tan Q;Zhang D;Swan GE;Krasnow R;Jang KL;Knafo-Noam A;Mankuta D;Abramson L;Lichtenstein P;Krueger RF;McGue M;Pahlen S;Tynelius P;Duncan GE;Buchwald D;Corley RP;Huibregtse BM;Nelson TL;Whitfield KE;Franz CE;Kremen WS;Lyons MJ;Ooki S;Brandt I;Nilsen TS;Inui F;Watanabe M;Bartels M;van Beijsterveldt TC;Wardle J;Llewellyn CH;Fisher A;Rebato E;Martin NG;Iwatani Y;Hayakawa K;Sung J;Harris JR;Willemsen G;Busjahn A;Goldberg JH;Rasmussen F;Hur YM;Boomsma DI;Sørensen TI;Kaprio J;Silventoinen K
一些但不是所有的研究表明，双卵（DZ）双胞胎的体型比单卵（MZ）双胞胎的体型大，这种差异也可能因年龄而异。我们分析了男性和女性双胞胎从婴儿到老年的身高和体重指数（BMI）的平均值和方差的卵性差异。数据来源于一个国际数据库，该数据库包含54个双胞胎队列，这些队列参与了双胞胎人体测量发展（CODATwins）的合作项目，其中包括842，951个1至102岁双胞胎的身高和BMI测量值。结果显示，DZ双胞胎的身高一直高于MZ双胞胎，儿童和青少年时期的差异高达2.0厘米，成年后高达0.9厘米。同样，在DZ双胞胎中观察到儿童和青少年的平均BMI高达0.3 kg/m2，成年后高达0.2 kg/m2，尽管模式不太一致。DZ双胞胎比MZ双胞胎的身高高1.7%，BMI高1.9%;这些百分比差异在儿童中期和晚期最大，并随着年龄的增长而下降。MZ和DZ双生子的身高在大多数年龄段的变异相似。相反，DZ双胞胎的BMI差异显著高于MZ双胞胎，尤其是在儿童期。总之，DZ双胞胎通常比MZ双胞胎更高，BMI更大，但随着年龄的增长，性别差异逐渐减小。
A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.