Chitooligosaccahrides: Digestion characterization and effect of the degree of polymerization on gut microorganisms to manage the metabolome functional diversity in vitro
Chitooligosaccahrides: Digestion characterization and effect of the degree of polymerization on gut microorganisms to manage the metabolome functional diversity in vitro
复制标题
壳寡糖：消化特性和聚合度对肠道微生物的影响，以管理体外代谢组功能多样性
DOI：
10.1016/j.carbpol.2021.118716
复制
发表时间：
2021-10-09
影响因子：
11.2
通讯作者：
Zhao, Liming
中科院分区：
文献类型：
--
作者：
Ji, Xiaoguo;Zhu, Liangliang;Zhao, Liming
壳寡糖（COS）的消费防止肠道微生态失调。不同COS对肠道微生物群的影响机制目前尚不清楚。本研究考察了不同聚合度的COS对肠道微生物群落和代谢特征的影响。COS对拟杆菌的生长有显著的促进作用，对变形菌的生长有显著的抑制作用，且与DP的浓度呈显著的正相关。COS 3和COS 2富集了由梭菌和副拟杆菌组成的微生物群落中的丁酸生产。由DP 4-6 COS富集的微生物群落显示出差异代谢物功能的多样性增加。几种生物标志物被显著区分，包括不饱和脂肪酸、胆汁酸、吲哚和胺，其主要与脂肪酸合成和分解、胆汁酸修饰和色氨酸代谢等过程相关。研究结果揭示了COS结构-肠道微生物-代谢组学之间的关系，为COS作为改善肠道健康的功能性食品提供了新的视角。
Consumption of chitooligosaccharides (COS) prevents intestinal microecological disorder. The mechanisms for the effects of different COS on the gut microbiota are currently unclear. This study examined the impact of COS with different degrees of polymerization (DPs) on the gut microbial community and metabolic profile. COS significantly promoted the growth of Bacteroidetes, and inhibited that of Proteobacteria, which were significantly correlated with DPs. COS3 and COS2 enriched the butyrate production in microbial communities composed of Clostridium and Parabacteroides. Microbial communities enriched by DPs 4-6 COS displayed increased diversity in differential metabolite function. Several biomarkers were distinguished significantly, including unsaturated fatty acids, bile acids, indoles and amines, which are mainly related to processes such as fatty acid synthesis and decomposition, bile acid modification, and tryptophan metabolism. The results display the relationship among COS structure-gut microbes-metabolomics, providing a new perspective for COS as a functional food to improve intestinal health.